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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MCM8 All Species: 37.58
Human Site: T572 Identified Species: 51.67
UniProt: Q9UJA3 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0.06
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UJA3 NP_115874.3 840 93697 T572 G H Y N K A K T V S E N L K M
Chimpanzee Pan troglodytes XP_001166964 840 93670 T572 G H Y N K A K T V S E N L K M
Rhesus Macaque Macaca mulatta XP_001115843 840 93650 T572 G H Y N K A K T V S E N L K M
Dog Lupus familis XP_534352 833 93150 T565 G H Y N K A K T V S E N L K M
Cat Felis silvestris
Mouse Mus musculus Q9CWV1 833 92353 T565 G H Y N K A R T V S E N L K M
Rat Rattus norvegicus NP_001099984 830 91958 T562 G H Y N K A R T V S E N L K M
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514432 828 92086 T560 G H Y N K A K T V S E N L K M
Chicken Gallus gallus XP_001232579 830 92790 A562 V G G H Y N K A K T V S E N L
Frog Xenopus laevis P55861 886 100243 T627 G R Y D P S L T F S E N V D L
Zebra Danio Brachydanio rerio XP_002665161 788 87122 S533 K M G S A L L S R F D L V F I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P49735 887 100396 T627 G R Y D P S M T F S E N V N L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34647 810 91112 I553 D Y A I A R R I L D N H R A I
Sea Urchin Strong. purpuratus XP_797782 848 93611 L578 A K T V S E N L K M S G P L L
Poplar Tree Populus trichocarpa XP_002326332 745 82557 A492 G L L A S L S A R T S V L A A
Maize Zea mays Q43704 768 85163 E515 G A R S L D K E G Y A E E D D
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FL33 776 86338 F523 D N A E S E M F V K Y N Q T L
Baker's Yeast Sacchar. cerevisiae P53091 1017 112934 S694 G R Y N R K L S L R G N L N M
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.2 97 92.2 N.A. 89.2 89.7 N.A. 82.9 77.8 28.6 68.9 N.A. 25.8 N.A. 24.2 64.5
Protein Similarity: 100 99.8 98 95.8 N.A. 94.4 94 N.A. 90.5 87.2 47.2 80.8 N.A. 44.7 N.A. 43.6 77.1
P-Site Identity: 100 100 100 100 N.A. 93.3 93.3 N.A. 100 6.6 40 0 N.A. 40 N.A. 0 0
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 33.3 66.6 33.3 N.A. 66.6 N.A. 33.3 6.6
Percent
Protein Identity: 43.4 27.1 N.A. 27.7 25 N.A.
Protein Similarity: 61.3 48.6 N.A. 48.6 42.9 N.A.
P-Site Identity: 13.3 13.3 N.A. 13.3 40 N.A.
P-Site Similarity: 20 20 N.A. 26.6 60 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 6 6 12 6 12 42 0 12 0 0 6 0 0 12 6 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 12 0 0 12 0 6 0 0 0 6 6 0 0 12 6 % D
% Glu: 0 0 0 6 0 12 0 6 0 0 53 6 12 0 0 % E
% Phe: 0 0 0 0 0 0 0 6 12 6 0 0 0 6 0 % F
% Gly: 71 6 12 0 0 0 0 0 6 0 6 6 0 0 0 % G
% His: 0 42 0 6 0 0 0 0 0 0 0 6 0 0 0 % H
% Ile: 0 0 0 6 0 0 0 6 0 0 0 0 0 0 12 % I
% Lys: 6 6 0 0 42 6 42 0 12 6 0 0 0 42 0 % K
% Leu: 0 6 6 0 6 12 18 6 12 0 0 6 53 6 30 % L
% Met: 0 6 0 0 0 0 12 0 0 6 0 0 0 0 48 % M
% Asn: 0 6 0 48 0 6 6 0 0 0 6 65 0 18 0 % N
% Pro: 0 0 0 0 12 0 0 0 0 0 0 0 6 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 6 0 0 % Q
% Arg: 0 18 6 0 6 6 18 0 12 6 0 0 6 0 0 % R
% Ser: 0 0 0 12 18 12 6 12 0 53 12 6 0 0 0 % S
% Thr: 0 0 6 0 0 0 0 53 0 12 0 0 0 6 0 % T
% Val: 6 0 0 6 0 0 0 0 48 0 6 6 18 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 6 59 0 6 0 0 0 0 6 6 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _