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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MCM8 All Species: 14.24
Human Site: Y201 Identified Species: 19.58
UniProt: Q9UJA3 Number Species: 16
    Phosphosite Substitution
    Charge Score: -0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UJA3 NP_115874.3 840 93697 Y201 I H A R V Y N Y E P L T Q L K
Chimpanzee Pan troglodytes XP_001166964 840 93670 Y201 I H A R V Y N Y E P L T Q L K
Rhesus Macaque Macaca mulatta XP_001115843 840 93650 Y201 I H A R V Y N Y E P L T Q L K
Dog Lupus familis XP_534352 833 93150 H199 Y N Y E P L T H L K N V R A N
Cat Felis silvestris
Mouse Mus musculus Q9CWV1 833 92353 L200 N Y E P L T H L K N I R A T C
Rat Rattus norvegicus NP_001099984 830 91958 I200 P L T H L K N I R A T C Y G K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514432 828 92086 G204 N V R A N F Y G K F V A L R G
Chicken Gallus gallus XP_001232579 830 92790 R202 L T Q L K N V R A N C Y G K Y
Frog Xenopus laevis P55861 886 100243 Y219 K E S L P V N Y E D L A A R E
Zebra Danio Brachydanio rerio XP_002665161 788 87122 M208 L P D G K Y T M P T K C L Q S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P49735 887 100396 R269 V T T E I H V R I S E L P L I
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34647 810 91112 I207 V D F Q K I R I Q E T Q A E L
Sea Urchin Strong. purpuratus XP_797782 848 93611 Y201 I H A R I L N Y E P T T A F K
Poplar Tree Populus trichocarpa XP_002326332 745 82557 F169 P L V V Q M N F N C A K C K Y
Maize Zea mays Q43704 768 85163 H192 G M C E Y K D H Q T L S M Q E
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FL33 776 86338 A200 Q E V P E N A A P G Q L P R S
Baker's Yeast Sacchar. cerevisiae P53091 1017 112934 L270 F Q I S F F N L P T V H R I R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.2 97 92.2 N.A. 89.2 89.7 N.A. 82.9 77.8 28.6 68.9 N.A. 25.8 N.A. 24.2 64.5
Protein Similarity: 100 99.8 98 95.8 N.A. 94.4 94 N.A. 90.5 87.2 47.2 80.8 N.A. 44.7 N.A. 43.6 77.1
P-Site Identity: 100 100 100 0 N.A. 0 13.3 N.A. 0 0 26.6 6.6 N.A. 6.6 N.A. 0 66.6
P-Site Similarity: 100 100 100 20 N.A. 33.3 20 N.A. 20 6.6 40 13.3 N.A. 26.6 N.A. 20 73.3
Percent
Protein Identity: 43.4 27.1 N.A. 27.7 25 N.A.
Protein Similarity: 61.3 48.6 N.A. 48.6 42.9 N.A.
P-Site Identity: 6.6 6.6 N.A. 0 6.6 N.A.
P-Site Similarity: 13.3 40 N.A. 0 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 24 6 0 0 6 6 6 6 6 12 24 6 0 % A
% Cys: 0 0 6 0 0 0 0 0 0 6 6 12 6 0 6 % C
% Asp: 0 6 6 0 0 0 6 0 0 6 0 0 0 0 0 % D
% Glu: 0 12 6 18 6 0 0 0 30 6 6 0 0 6 12 % E
% Phe: 6 0 6 0 6 12 0 6 0 6 0 0 0 6 0 % F
% Gly: 6 0 0 6 0 0 0 6 0 6 0 0 6 6 6 % G
% His: 0 24 0 6 0 6 6 12 0 0 0 6 0 0 0 % H
% Ile: 24 0 6 0 12 6 0 12 6 0 6 0 0 6 6 % I
% Lys: 6 0 0 0 18 12 0 0 12 6 6 6 0 12 30 % K
% Leu: 12 12 0 12 12 12 0 12 6 0 30 12 12 24 6 % L
% Met: 0 6 0 0 0 6 0 6 0 0 0 0 6 0 0 % M
% Asn: 12 6 0 0 6 12 48 0 6 12 6 0 0 0 6 % N
% Pro: 12 6 0 12 12 0 0 0 18 24 0 0 12 0 0 % P
% Gln: 6 6 6 6 6 0 0 0 12 0 6 6 18 12 0 % Q
% Arg: 0 0 6 24 0 0 6 12 6 0 0 6 12 18 6 % R
% Ser: 0 0 6 6 0 0 0 0 0 6 0 6 0 0 12 % S
% Thr: 0 12 12 0 0 6 12 0 0 18 18 24 0 6 0 % T
% Val: 12 6 12 6 18 6 12 0 0 0 12 6 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 6 6 6 0 6 24 6 30 0 0 0 6 6 0 12 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _