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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM8
All Species:
10
Human Site:
Y218
Identified Species:
13.75
UniProt:
Q9UJA3
Number Species:
16
Phosphosite Substitution
Charge Score:
-0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UJA3
NP_115874.3
840
93697
Y218
R
A
N
Y
Y
G
K
Y
I
A
L
R
G
T
V
Chimpanzee
Pan troglodytes
XP_001166964
840
93670
Y218
R
A
N
Y
Y
G
K
Y
I
A
L
R
G
T
V
Rhesus Macaque
Macaca mulatta
XP_001115843
840
93650
Y218
R
A
N
Y
Y
G
K
Y
I
A
L
R
G
T
V
Dog
Lupus familis
XP_534352
833
93150
G216
G
K
Y
I
A
L
R
G
T
V
V
R
V
S
N
Cat
Felis silvestris
Mouse
Mus musculus
Q9CWV1
833
92353
T217
K
Y
I
S
I
R
G
T
V
V
R
V
S
N
I
Rat
Rattus norvegicus
NP_001099984
830
91958
R217
S
I
R
G
T
V
V
R
V
S
N
I
K
P
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514432
828
92086
P221
V
R
V
G
N
I
K
P
L
C
T
K
M
A
F
Chicken
Gallus gallus
XP_001232579
830
92790
V219
L
R
G
T
V
V
R
V
S
N
I
K
P
L
C
Frog
Xenopus laevis
P55861
886
100243
A236
L
A
Y
F
L
P
E
A
P
A
E
M
L
K
I
Zebra Danio
Brachydanio rerio
XP_002665161
788
87122
N225
R
G
R
S
F
T
P
N
R
S
S
P
F
T
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49735
887
100396
H286
L
R
T
F
R
K
L
H
L
N
Q
L
V
R
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34647
810
91112
D224
G
S
I
P
R
T
V
D
V
I
V
R
G
E
M
Sea Urchin
Strong. purpuratus
XP_797782
848
93611
F218
K
A
N
C
Y
G
K
F
V
S
V
K
G
T
V
Poplar Tree
Populus trichocarpa
XP_002326332
745
82557
K186
L
R
I
F
P
D
G
K
F
S
P
P
T
V
C
Maize
Zea mays
Q43704
768
85163
L209
E
N
S
A
P
G
Q
L
P
R
T
V
D
V
I
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FL33
776
86338
V217
V
I
A
E
D
D
L
V
D
S
C
K
P
G
D
Baker's Yeast
Sacchar. cerevisiae
P53091
1017
112934
L287
R
S
E
K
I
G
S
L
L
S
I
S
G
T
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
97
92.2
N.A.
89.2
89.7
N.A.
82.9
77.8
28.6
68.9
N.A.
25.8
N.A.
24.2
64.5
Protein Similarity:
100
99.8
98
95.8
N.A.
94.4
94
N.A.
90.5
87.2
47.2
80.8
N.A.
44.7
N.A.
43.6
77.1
P-Site Identity:
100
100
100
6.6
N.A.
0
0
N.A.
6.6
0
13.3
13.3
N.A.
0
N.A.
13.3
53.3
P-Site Similarity:
100
100
100
26.6
N.A.
20
20
N.A.
20
20
33.3
33.3
N.A.
20
N.A.
40
93.3
Percent
Protein Identity:
43.4
27.1
N.A.
27.7
25
N.A.
Protein Similarity:
61.3
48.6
N.A.
48.6
42.9
N.A.
P-Site Identity:
0
6.6
N.A.
0
33.3
N.A.
P-Site Similarity:
13.3
26.6
N.A.
13.3
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
30
6
6
6
0
0
6
0
24
0
0
0
6
0
% A
% Cys:
0
0
0
6
0
0
0
0
0
6
6
0
0
0
12
% C
% Asp:
0
0
0
0
6
12
0
6
6
0
0
0
6
0
6
% D
% Glu:
6
0
6
6
0
0
6
0
0
0
6
0
0
6
0
% E
% Phe:
0
0
0
18
6
0
0
6
6
0
0
0
6
0
6
% F
% Gly:
12
6
6
12
0
36
12
6
0
0
0
0
36
6
0
% G
% His:
0
0
0
0
0
0
0
6
0
0
0
0
0
0
0
% H
% Ile:
0
12
18
6
12
6
0
0
18
6
12
6
0
0
18
% I
% Lys:
12
6
0
6
0
6
30
6
0
0
0
24
6
6
0
% K
% Leu:
24
0
0
0
6
6
12
12
18
0
18
6
6
6
12
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
6
6
0
6
% M
% Asn:
0
6
24
0
6
0
0
6
0
12
6
0
0
6
6
% N
% Pro:
0
0
0
6
12
6
6
6
12
0
6
12
12
6
0
% P
% Gln:
0
0
0
0
0
0
6
0
0
0
6
0
0
0
0
% Q
% Arg:
30
24
12
0
12
6
12
6
6
6
6
30
0
6
0
% R
% Ser:
6
12
6
12
0
0
6
0
6
36
6
6
6
6
0
% S
% Thr:
0
0
6
6
6
12
0
6
6
0
12
0
6
36
6
% T
% Val:
12
0
6
0
6
12
12
12
24
12
18
12
12
12
30
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
6
12
18
24
0
0
18
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _