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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ANAPC2 All Species: 27.58
Human Site: Y125 Identified Species: 55.15
UniProt: Q9UJX6 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UJX6 NP_037498.1 822 93828 Y125 L E S R L D P Y L R S L E L L
Chimpanzee Pan troglodytes XP_520643 822 93623 Y125 L E S R L D P Y L R S L E L L
Rhesus Macaque Macaca mulatta XP_001089959 822 93819 Y125 L E S R L D P Y L R S L E L L
Dog Lupus familis XP_548357 818 93512 Y121 L E S R L D P Y L R S L E L L
Cat Felis silvestris
Mouse Mus musculus Q8BZQ7 837 95302 Y140 L E S R L D P Y L H S L E L L
Rat Rattus norvegicus NP_001094002 836 95354 Y139 L E S R L D P Y L H S L E L L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_415533 810 92419 Y113 L K C R L E P Y L S S M E L L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_002662165 802 90907 G108 Q Q L E P F L G G L E K L G S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_395411 604 69914
Nematode Worm Caenorhab. elegans P34514 731 84494 Y96 V I K V L R P Y F M S H F T N
Sea Urchin Strong. purpuratus XP_795679 445 51396
Poplar Tree Populus trichocarpa XP_002311316 870 97541 K123 L E K Q Y Q E K C L L L L V R
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95.9 99.3 95.2 N.A. 92.7 93.5 N.A. N.A. 70.3 N.A. 54.8 N.A. N.A. 36.9 25.2 28.8
Protein Similarity: 100 97 99.7 97.1 N.A. 94.9 95.6 N.A. N.A. 84 N.A. 71.6 N.A. N.A. 53.1 45.1 40.8
P-Site Identity: 100 100 100 100 N.A. 93.3 93.3 N.A. N.A. 66.6 N.A. 0 N.A. N.A. 0 26.6 0
P-Site Similarity: 100 100 100 100 N.A. 93.3 93.3 N.A. N.A. 86.6 N.A. 6.6 N.A. N.A. 0 33.3 0
Percent
Protein Identity: 32 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 51.2 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 20 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 33.3 N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 9 0 0 0 0 0 9 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 50 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 59 0 9 0 9 9 0 0 0 9 0 59 0 0 % E
% Phe: 0 0 0 0 0 9 0 0 9 0 0 0 9 0 0 % F
% Gly: 0 0 0 0 0 0 0 9 9 0 0 0 0 9 0 % G
% His: 0 0 0 0 0 0 0 0 0 17 0 9 0 0 0 % H
% Ile: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 9 17 0 0 0 0 9 0 0 0 9 0 0 0 % K
% Leu: 67 0 9 0 67 0 9 0 59 17 9 59 17 59 59 % L
% Met: 0 0 0 0 0 0 0 0 0 9 0 9 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % N
% Pro: 0 0 0 0 9 0 67 0 0 0 0 0 0 0 0 % P
% Gln: 9 9 0 9 0 9 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 59 0 9 0 0 0 34 0 0 0 0 9 % R
% Ser: 0 0 50 0 0 0 0 0 0 9 67 0 0 0 9 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % T
% Val: 9 0 0 9 0 0 0 0 0 0 0 0 0 9 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 9 0 0 67 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _