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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DBR1 All Species: 25.76
Human Site: S274 Identified Species: 40.48
UniProt: Q9UK59 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UK59 NP_057300.2 544 61555 S274 L E I E H D P S A P D Y L E Y
Chimpanzee Pan troglodytes XP_526319 545 61694 S274 L E I E H D P S A P D Y L E Y
Rhesus Macaque Macaca mulatta XP_001114637 544 61581 S274 L E I E H D P S A P D Y L E Y
Dog Lupus familis XP_852077 544 61645 N274 I E I D H D P N A P E Y L E Y
Cat Felis silvestris
Mouse Mus musculus Q923B1 550 62271 S274 L E I E H D P S A P E Y L E Y
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519946 524 58844 S243 I D I E H D S S A P D Y L E Y
Chicken Gallus gallus Q5ZLM2 536 60758 T274 I D I E H D P T A G D S L E Y
Frog Xenopus laevis Q6GPB8 534 61070 S273 V D M E H D P S K P E C L E Y
Zebra Danio Brachydanio rerio Q7T3E4 568 62871 G273 V E V A D R P G S S E Q L E Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VSD7 534 59444 A268 E R E K V K K A A P V P P P S
Honey Bee Apis mellifera XP_623894 478 54582 A225 Y P N Y W F S A H L H C K F A
Nematode Worm Caenorhab. elegans Q966M6 500 56663 F244 L F R K K D L F E A D H N S G
Sea Urchin Strong. purpuratus XP_782666 646 72191 E273 L E F P E K S E R P F E L S Y
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q94K01 418 48157 I170 Q L E E P L D I F L S H D W P
Baker's Yeast Sacchar. cerevisiae P24309 405 47723 H157 A N I R N L Y H V R I S D I A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.2 98.7 90.2 N.A. 85.4 N.A. N.A. 67.6 71.5 64.8 56.5 N.A. 35.6 45.9 35.2 43
Protein Similarity: 100 99.6 99 95.5 N.A. 90.9 N.A. N.A. 77.9 82.5 80.1 70.9 N.A. 51.8 61 53.1 58.6
P-Site Identity: 100 100 100 73.3 N.A. 93.3 N.A. N.A. 80 66.6 60 33.3 N.A. 13.3 0 20 33.3
P-Site Similarity: 100 100 100 100 N.A. 100 N.A. N.A. 93.3 86.6 86.6 60 N.A. 26.6 6.6 33.3 33.3
Percent
Protein Identity: N.A. N.A. N.A. 41.5 29.4 N.A.
Protein Similarity: N.A. N.A. N.A. 54.7 47.9 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 7 0 0 0 14 54 7 0 0 0 0 14 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 14 0 0 0 % C
% Asp: 0 20 0 7 7 60 7 0 0 0 40 0 14 0 0 % D
% Glu: 7 47 14 54 7 0 0 7 7 0 27 7 0 60 0 % E
% Phe: 0 7 7 0 0 7 0 7 7 0 7 0 0 7 0 % F
% Gly: 0 0 0 0 0 0 0 7 0 7 0 0 0 0 7 % G
% His: 0 0 0 0 54 0 0 7 7 0 7 14 0 0 0 % H
% Ile: 20 0 54 0 0 0 0 7 0 0 7 0 0 7 0 % I
% Lys: 0 0 0 14 7 14 7 0 7 0 0 0 7 0 0 % K
% Leu: 40 7 0 0 0 14 7 0 0 14 0 0 67 0 0 % L
% Met: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 7 7 0 7 0 0 7 0 0 0 0 7 0 0 % N
% Pro: 0 7 0 7 7 0 54 0 0 60 0 7 7 7 7 % P
% Gln: 7 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % Q
% Arg: 0 7 7 7 0 7 0 0 7 7 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 20 40 7 7 7 14 0 14 7 % S
% Thr: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % T
% Val: 14 0 7 0 7 0 0 0 7 0 7 0 0 0 0 % V
% Trp: 0 0 0 0 7 0 0 0 0 0 0 0 0 7 0 % W
% Tyr: 7 0 0 7 0 0 7 0 0 0 0 40 0 0 67 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _