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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
APPL1
All Species:
12.42
Human Site:
Y522
Identified Species:
39.05
UniProt:
Q9UKG1
Number Species:
7
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UKG1
NP_036228.1
709
79663
Y522
D
D
H
P
D
V
V
Y
E
T
M
R
Q
I
L
Chimpanzee
Pan troglodytes
XP_516550
692
77782
A513
E
T
M
R
Q
I
L
A
A
R
A
I
H
N
I
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_849075
708
79602
Y521
D
D
S
P
D
V
V
Y
E
T
M
R
Q
I
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8K3H0
707
79310
Y521
D
D
H
P
D
V
V
Y
E
T
M
R
Q
I
L
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518632
501
55997
H336
I
F
R
M
T
E
S
H
L
L
V
T
C
D
C
Chicken
Gallus gallus
Q5ZK62
781
88436
P533
E
S
R
T
K
V
L
P
Q
S
Q
E
E
K
R
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001121546
707
79275
Y519
T
E
S
S
D
V
I
Y
E
T
M
R
Q
I
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784602
759
84098
M541
D
K
G
L
D
V
L
M
Q
T
I
R
H
I
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.5
N.A.
98.3
N.A.
98
N.A.
N.A.
61.9
20.1
N.A.
80.2
N.A.
N.A.
N.A.
N.A.
36.5
Protein Similarity:
100
97.5
N.A.
98.8
N.A.
98.8
N.A.
N.A.
65.3
40.5
N.A.
90.9
N.A.
N.A.
N.A.
N.A.
55.7
P-Site Identity:
100
0
N.A.
93.3
N.A.
100
N.A.
N.A.
0
6.6
N.A.
66.6
N.A.
N.A.
N.A.
N.A.
40
P-Site Similarity:
100
26.6
N.A.
93.3
N.A.
100
N.A.
N.A.
13.3
40
N.A.
80
N.A.
N.A.
N.A.
N.A.
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
13
13
0
13
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
13
0
13
% C
% Asp:
50
38
0
0
63
0
0
0
0
0
0
0
0
13
0
% D
% Glu:
25
13
0
0
0
13
0
0
50
0
0
13
13
0
0
% E
% Phe:
0
13
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
13
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
25
0
0
0
0
13
0
0
0
0
25
0
0
% H
% Ile:
13
0
0
0
0
13
13
0
0
0
13
13
0
63
13
% I
% Lys:
0
13
0
0
13
0
0
0
0
0
0
0
0
13
0
% K
% Leu:
0
0
0
13
0
0
38
0
13
13
0
0
0
0
50
% L
% Met:
0
0
13
13
0
0
0
13
0
0
50
0
0
0
13
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
13
0
% N
% Pro:
0
0
0
38
0
0
0
13
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
13
0
0
0
25
0
13
0
50
0
0
% Q
% Arg:
0
0
25
13
0
0
0
0
0
13
0
63
0
0
13
% R
% Ser:
0
13
25
13
0
0
13
0
0
13
0
0
0
0
0
% S
% Thr:
13
13
0
13
13
0
0
0
0
63
0
13
0
0
0
% T
% Val:
0
0
0
0
0
75
38
0
0
0
13
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
50
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _