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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CROT All Species: 22.73
Human Site: S22 Identified Species: 38.46
UniProt: Q9UKG9 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.31
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UKG9 NP_066974.2 612 70178 S22 Q Y Q D S L P S L P V P S L E
Chimpanzee Pan troglodytes XP_519181 612 70113 S22 Q Y Q D S L P S L P V P S L E
Rhesus Macaque Macaca mulatta XP_001106063 612 70108 S22 Q Y Q D S L P S L P V P S L K
Dog Lupus familis XP_539402 612 70074 S22 Q Y Q D S L P S L P V P S L E
Cat Felis silvestris
Mouse Mus musculus Q9DC50 612 70246 S22 Q Y Q D S L P S L P V P A L E
Rat Rattus norvegicus P11466 612 70284 P22 Q Y Q D S L P P L P V P S L E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508909 667 75073 P22 Q Y Q D S L P P L P V P S L E
Chicken Gallus gallus Q90YJ9 640 72605 K25 K D E P A V P K L P V P P L Q
Frog Xenopus laevis Q7ZXE1 659 74538 R53 H F Q K S L P R L P I P K F E
Zebra Danio Brachydanio rerio B2ZGJ1 637 71821 L30 I P P L K Q T L D M Y L T C M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P07668 721 81310 K90 G F P D T L P K V P V P A L D
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P32756 627 71299 K22 W Y E T A L P K P P V P S L E
Sea Urchin Strong. purpuratus XP_790326 610 68809 S26 L P P L P V P S L Q Q T L H K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32796 670 77223 S76 A K Q Q D L P S L P V P E L K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 97.3 84.6 N.A. 85.6 84.8 N.A. 68.8 29.2 27.7 28.5 N.A. 25.9 N.A. 27.7 45.1
Protein Similarity: 100 99.8 99 91.1 N.A. 93.1 92.4 N.A. 79.1 49.5 46.2 49.9 N.A. 45.6 N.A. 46.8 63.5
P-Site Identity: 100 100 93.3 100 N.A. 93.3 93.3 N.A. 93.3 40 53.3 0 N.A. 46.6 N.A. 60 20
P-Site Similarity: 100 100 100 100 N.A. 100 93.3 N.A. 93.3 73.3 66.6 6.6 N.A. 80 N.A. 73.3 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 24.6 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 42.6 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 60 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 66.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 15 0 0 0 0 0 0 0 15 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % C
% Asp: 0 8 0 58 8 0 0 0 8 0 0 0 0 0 8 % D
% Glu: 0 0 15 0 0 0 0 0 0 0 0 0 8 0 58 % E
% Phe: 0 15 0 0 0 0 0 0 0 0 0 0 0 8 0 % F
% Gly: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 8 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % H
% Ile: 8 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % I
% Lys: 8 8 0 8 8 0 0 22 0 0 0 0 8 0 22 % K
% Leu: 8 0 0 15 0 79 0 8 79 0 0 8 8 79 0 % L
% Met: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 8 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 15 22 8 8 0 93 15 8 86 0 86 8 0 0 % P
% Gln: 50 0 65 8 0 8 0 0 0 8 8 0 0 0 8 % Q
% Arg: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 58 0 0 50 0 0 0 0 50 0 0 % S
% Thr: 0 0 0 8 8 0 8 0 0 0 0 8 8 0 0 % T
% Val: 0 0 0 0 0 15 0 0 8 0 79 0 0 0 0 % V
% Trp: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 58 0 0 0 0 0 0 0 0 8 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _