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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CROT All Species: 25.76
Human Site: S282 Identified Species: 43.59
UniProt: Q9UKG9 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.31
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UKG9 NP_066974.2 612 70178 S282 V Y S M E D S S P H V T P E D
Chimpanzee Pan troglodytes XP_519181 612 70113 S282 V Y S M E D S S P H V T P E D
Rhesus Macaque Macaca mulatta XP_001106063 612 70108 S282 V Y S M E D D S P H V T P E D
Dog Lupus familis XP_539402 612 70074 S282 V Y S I E D S S P H V T P G N
Cat Felis silvestris
Mouse Mus musculus Q9DC50 612 70246 S282 V Y S I E D S S P H A T P E E
Rat Rattus norvegicus P11466 612 70284 S282 V Y S I E D T S P H A T P E N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508909 667 75073 S282 V Y S L D D A S P Q V T P E D
Chicken Gallus gallus Q90YJ9 640 72605 E289 L D G T S G V E L N D T N M A
Frog Xenopus laevis Q7ZXE1 659 74538 P333 C L C L D D F P I K D R V H L
Zebra Danio Brachydanio rerio B2ZGJ1 637 71821 E284 L D E E T A T E L N D S N R A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P07668 721 81310 D374 P T V H R A G D R D E T N M A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P32756 627 71299 D280 V V C L D M E D P I D Y G K N
Sea Urchin Strong. purpuratus XP_790326 610 68809 H282 G C I M D D G H P T T M A G T
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32796 670 77223 Q336 M L C L D L D Q S P V T L E E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 97.3 84.6 N.A. 85.6 84.8 N.A. 68.8 29.2 27.7 28.5 N.A. 25.9 N.A. 27.7 45.1
Protein Similarity: 100 99.8 99 91.1 N.A. 93.1 92.4 N.A. 79.1 49.5 46.2 49.9 N.A. 45.6 N.A. 46.8 63.5
P-Site Identity: 100 100 93.3 80 N.A. 80 73.3 N.A. 73.3 6.6 6.6 0 N.A. 6.6 N.A. 13.3 20
P-Site Similarity: 100 100 93.3 93.3 N.A. 93.3 93.3 N.A. 93.3 20 20 26.6 N.A. 6.6 N.A. 40 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 24.6 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 42.6 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 20 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 15 8 0 0 0 15 0 8 0 22 % A
% Cys: 8 8 22 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 15 0 0 36 65 15 15 0 8 29 0 0 0 29 % D
% Glu: 0 0 8 8 43 0 8 15 0 0 8 0 0 50 15 % E
% Phe: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % F
% Gly: 8 0 8 0 0 8 15 0 0 0 0 0 8 15 0 % G
% His: 0 0 0 8 0 0 0 8 0 43 0 0 0 8 0 % H
% Ile: 0 0 8 22 0 0 0 0 8 8 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 8 0 0 0 8 0 % K
% Leu: 15 15 0 29 0 8 0 0 15 0 0 0 8 0 8 % L
% Met: 8 0 0 29 0 8 0 0 0 0 0 8 0 15 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 15 0 0 22 0 22 % N
% Pro: 8 0 0 0 0 0 0 8 65 8 0 0 50 0 0 % P
% Gln: 0 0 0 0 0 0 0 8 0 8 0 0 0 0 0 % Q
% Arg: 0 0 0 0 8 0 0 0 8 0 0 8 0 8 0 % R
% Ser: 0 0 50 0 8 0 29 50 8 0 0 8 0 0 0 % S
% Thr: 0 8 0 8 8 0 15 0 0 8 8 72 0 0 8 % T
% Val: 58 8 8 0 0 0 8 0 0 0 43 0 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 50 0 0 0 0 0 0 0 0 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _