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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CROT All Species: 24.24
Human Site: S473 Identified Species: 41.03
UniProt: Q9UKG9 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UKG9 NP_066974.2 612 70178 S473 C Q S M Q D P S V N L R E R Q
Chimpanzee Pan troglodytes XP_519181 612 70113 S473 C Q S M Q D P S V N L H E Q Q
Rhesus Macaque Macaca mulatta XP_001106063 612 70108 S473 C Q S M Q D P S V S L H E R Q
Dog Lupus familis XP_539402 612 70074 S473 C Q S M Q D P S T S F L E Q Q
Cat Felis silvestris
Mouse Mus musculus Q9DC50 612 70246 S473 C Q S M Q D P S A S L L E R Q
Rat Rattus norvegicus P11466 612 70284 S473 C Q S M Q D P S A S L L E R Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508909 667 75073 S473 C K I M A D P S T C P L Q R Q
Chicken Gallus gallus Q90YJ9 640 72605 K480 V K A M I D D K P A L S D S E
Frog Xenopus laevis Q7ZXE1 659 74538 P522 S E A L V M N P S K H S P A E
Zebra Danio Brachydanio rerio B2ZGJ1 637 71821 S475 V K A M A S G S K I T D A E K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P07668 721 81310 E564 A K A M C Q G E G A N V P L E
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P32756 627 71299 K486 V T A M A S K K E S K E R K L
Sea Urchin Strong. purpuratus XP_790326 610 68809 R471 C K A M L D S R A D P T H Q L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32796 670 77223 D528 V S K W Q N G D V P I A E K I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 97.3 84.6 N.A. 85.6 84.8 N.A. 68.8 29.2 27.7 28.5 N.A. 25.9 N.A. 27.7 45.1
Protein Similarity: 100 99.8 99 91.1 N.A. 93.1 92.4 N.A. 79.1 49.5 46.2 49.9 N.A. 45.6 N.A. 46.8 63.5
P-Site Identity: 100 86.6 86.6 66.6 N.A. 80 80 N.A. 46.6 20 0 13.3 N.A. 6.6 N.A. 6.6 20
P-Site Similarity: 100 93.3 93.3 80 N.A. 86.6 86.6 N.A. 60 46.6 26.6 33.3 N.A. 26.6 N.A. 26.6 46.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 24.6 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 42.6 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 20 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 43 0 22 0 0 0 22 15 0 8 8 8 0 % A
% Cys: 58 0 0 0 8 0 0 0 0 8 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 65 8 8 0 8 0 8 8 0 0 % D
% Glu: 0 8 0 0 0 0 0 8 8 0 0 8 50 8 22 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 22 0 8 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 8 15 8 0 0 % H
% Ile: 0 0 8 0 8 0 0 0 0 8 8 0 0 0 8 % I
% Lys: 0 36 8 0 0 0 8 15 8 8 8 0 0 15 8 % K
% Leu: 0 0 0 8 8 0 0 0 0 0 43 29 0 8 15 % L
% Met: 0 0 0 86 0 8 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 8 8 0 0 15 8 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 50 8 8 8 15 0 15 0 0 % P
% Gln: 0 43 0 0 50 8 0 0 0 0 0 0 8 22 50 % Q
% Arg: 0 0 0 0 0 0 0 8 0 0 0 8 8 36 0 % R
% Ser: 8 8 43 0 0 15 8 58 8 36 0 15 0 8 0 % S
% Thr: 0 8 0 0 0 0 0 0 15 0 8 8 0 0 0 % T
% Val: 29 0 0 0 8 0 0 0 29 0 0 8 0 0 0 % V
% Trp: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _