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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CROT All Species: 21.21
Human Site: T409 Identified Species: 35.9
UniProt: Q9UKG9 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UKG9 NP_066974.2 612 70178 T409 T S F G K K L T K N K M L H P
Chimpanzee Pan troglodytes XP_519181 612 70113 T409 T S F G K K L T K N K M L H P
Rhesus Macaque Macaca mulatta XP_001106063 612 70108 T409 T S F G K K L T K N K M L H P
Dog Lupus familis XP_539402 612 70074 T409 T S F G K K L T K K K M L H P
Cat Felis silvestris
Mouse Mus musculus Q9DC50 612 70246 T409 T S F G K K L T K E E A L H P
Rat Rattus norvegicus P11466 612 70284 T409 T S F G K K L T K K E A L H P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508909 667 75073 L409 T T F G K M L L K K K R L H P
Chicken Gallus gallus Q90YJ9 640 72605 I416 V N Y G K E F I K K Q K T S P
Frog Xenopus laevis Q7ZXE1 659 74538 L458 K K G G K E F L K T Q K L S P
Zebra Danio Brachydanio rerio B2ZGJ1 637 71821 I411 T G Y G K E F I K R Q K M S P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P07668 721 81310 I500 Q S Y G K T F I K S C Q V S P
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P32756 627 71299 I422 N E F G K D S I K N W R V S P
Sea Urchin Strong. purpuratus XP_790326 610 68809 M407 Y Q Y G K D F M K K H K M H P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32796 670 77223 I464 N K Y G K T F I K R H G M S P
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 97.3 84.6 N.A. 85.6 84.8 N.A. 68.8 29.2 27.7 28.5 N.A. 25.9 N.A. 27.7 45.1
Protein Similarity: 100 99.8 99 91.1 N.A. 93.1 92.4 N.A. 79.1 49.5 46.2 49.9 N.A. 45.6 N.A. 46.8 63.5
P-Site Identity: 100 100 100 93.3 N.A. 80 80 N.A. 66.6 26.6 33.3 33.3 N.A. 33.3 N.A. 40 33.3
P-Site Similarity: 100 100 100 93.3 N.A. 86.6 86.6 N.A. 73.3 53.3 46.6 60 N.A. 53.3 N.A. 46.6 46.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 24.6 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 42.6 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 26.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 15 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % C
% Asp: 0 0 0 0 0 15 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 8 0 0 0 22 0 0 0 8 15 0 0 0 0 % E
% Phe: 0 0 58 0 0 0 43 0 0 0 0 0 0 0 0 % F
% Gly: 0 8 8 100 0 0 0 0 0 0 0 8 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 15 0 0 58 0 % H
% Ile: 0 0 0 0 0 0 0 36 0 0 0 0 0 0 0 % I
% Lys: 8 15 0 0 100 43 0 0 100 36 36 29 0 0 0 % K
% Leu: 0 0 0 0 0 0 50 15 0 0 0 0 58 0 0 % L
% Met: 0 0 0 0 0 8 0 8 0 0 0 29 22 0 0 % M
% Asn: 15 8 0 0 0 0 0 0 0 29 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 100 % P
% Gln: 8 8 0 0 0 0 0 0 0 0 22 8 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 15 0 15 0 0 0 % R
% Ser: 0 50 0 0 0 0 8 0 0 8 0 0 0 43 0 % S
% Thr: 58 8 0 0 0 15 0 43 0 8 0 0 8 0 0 % T
% Val: 8 0 0 0 0 0 0 0 0 0 0 0 15 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % W
% Tyr: 8 0 36 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _