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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDC42EP3
All Species:
8.18
Human Site:
S220
Identified Species:
20
UniProt:
Q9UKI2
Number Species:
9
Phosphosite Substitution
Charge Score:
0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UKI2
NP_006440.2
254
27678
S220
L
I
K
G
K
T
K
S
E
E
S
L
S
D
L
Chimpanzee
Pan troglodytes
XP_001169517
210
22488
S182
S
N
A
S
S
L
L
S
L
H
V
D
L
G
P
Rhesus Macaque
Macaca mulatta
XP_001113902
210
22479
S182
S
H
A
S
S
L
L
S
L
H
V
D
L
G
P
Dog
Lupus familis
XP_532935
253
27435
E220
L
V
K
K
T
K
S
E
E
S
L
S
D
L
T
Cat
Felis silvestris
Mouse
Mus musculus
Q9CQC5
254
27667
S220
L
V
K
S
K
T
K
S
E
E
S
F
S
D
L
Rat
Rattus norvegicus
Q5PQP4
214
23030
S186
S
H
A
S
S
L
L
S
L
H
V
D
L
G
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510360
257
27876
E221
G
L
G
K
G
K
S
E
S
E
P
S
L
S
E
Chicken
Gallus gallus
XP_426134
253
27922
E220
L
T
K
T
K
S
E
E
S
L
S
D
L
A
G
Frog
Xenopus laevis
NP_001088607
256
27996
K220
E
I
E
S
P
D
M
K
P
E
E
P
L
S
D
Zebra Danio
Brachydanio rerio
NP_001004568
300
32896
S265
I
S
K
S
K
S
Q
S
Q
E
S
L
P
Q
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
41.7
41.7
93.6
N.A.
92.5
40.9
N.A.
75
76.7
71.4
46.3
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
51.5
51.5
95.6
N.A.
95.2
51.5
N.A.
83.2
83.8
80.4
60.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
6.6
6.6
20
N.A.
80
6.6
N.A.
6.6
26.6
13.3
40
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
6.6
6.6
26.6
N.A.
86.6
6.6
N.A.
13.3
40
20
73.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
30
0
0
0
0
0
0
0
0
0
0
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
10
0
0
0
0
0
40
10
20
10
% D
% Glu:
10
0
10
0
0
0
10
30
30
50
10
0
0
0
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% F
% Gly:
10
0
10
10
10
0
0
0
0
0
0
0
0
30
10
% G
% His:
0
20
0
0
0
0
0
0
0
30
0
0
0
0
0
% H
% Ile:
10
20
0
0
0
0
0
0
0
0
0
0
0
0
10
% I
% Lys:
0
0
50
20
40
20
20
10
0
0
0
0
0
0
0
% K
% Leu:
40
10
0
0
0
30
30
0
30
10
10
20
60
10
20
% L
% Met:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% M
% Asn:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
10
0
0
0
10
0
10
10
10
0
30
% P
% Gln:
0
0
0
0
0
0
10
0
10
0
0
0
0
10
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
30
10
0
60
30
20
20
60
20
10
40
20
20
20
0
% S
% Thr:
0
10
0
10
10
20
0
0
0
0
0
0
0
0
10
% T
% Val:
0
20
0
0
0
0
0
0
0
0
30
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _