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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AMFR All Species: 16.36
Human Site: S516 Identified Species: 25.71
UniProt: Q9UKV5 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UKV5 NP_001135.3 643 72996 S516 S I R P A L N S P V E R P S S
Chimpanzee Pan troglodytes XP_001135064 580 66233 S453 S I R P A L N S P V E R P S S
Rhesus Macaque Macaca mulatta XP_001091030 552 63193 Q442 E E G E T S A Q T E R V P L D
Dog Lupus familis XP_544395 453 51620 E343 G E A S V Q T E R V P L D L S
Cat Felis silvestris
Mouse Mus musculus Q9R049 643 73087 S516 S L R P A L N S P V E R P S P
Rat Rattus norvegicus Q6Y290 419 46430 L309 P M C K L N I L K A L G I V P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_414064 763 87868 S636 A V R P A S N S S V E R H S A
Frog Xenopus laevis Q5XHH7 595 65901 A478 H E R Q N L E A R L Q C L Q N
Zebra Danio Brachydanio rerio Q803I8 625 68739 T504 Q C L H N I H T L L D A A M L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q95SP2 626 69254 S496 D S A G I M M S Q Y Q S L S A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P90859 564 64691 M453 Q M S V D I I M T D L R Q S G
Sea Urchin Strong. purpuratus XP_792411 845 93984 A633 A E A T D Q P A Q A P P G S F
Poplar Tree Populus trichocarpa XP_002303501 581 64513 A459 S G Q G A D G A G P S T A M R
Maize Zea mays NP_001137060 503 56440 Y393 L Y G R S F V Y P P A N T L N
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_849843 460 52108 H350 A S G N R G P H Q E S L Q Q G
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 85.2 84.5 66.5 N.A. 94.4 20.2 N.A. N.A. 69.8 20.2 23.7 N.A. 23 N.A. 21.7 40.5
Protein Similarity: 100 85.2 84.7 67.8 N.A. 96.5 34.8 N.A. N.A. 76.1 36.7 39.9 N.A. 42.6 N.A. 42.4 52.7
P-Site Identity: 100 100 6.6 13.3 N.A. 86.6 0 N.A. N.A. 60 13.3 0 N.A. 13.3 N.A. 13.3 6.6
P-Site Similarity: 100 100 6.6 13.3 N.A. 93.3 6.6 N.A. N.A. 80 40 33.3 N.A. 33.3 N.A. 26.6 20
Percent
Protein Identity: 23.7 24.5 N.A. 25.3 N.A. N.A.
Protein Similarity: 41.5 40.2 N.A. 40.7 N.A. N.A.
P-Site Identity: 13.3 6.6 N.A. 0 N.A. N.A.
P-Site Similarity: 26.6 20 N.A. 6.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 20 0 20 0 34 0 7 20 0 14 7 7 14 0 14 % A
% Cys: 0 7 7 0 0 0 0 0 0 0 0 7 0 0 0 % C
% Asp: 7 0 0 0 14 7 0 0 0 7 7 0 7 0 7 % D
% Glu: 7 27 0 7 0 0 7 7 0 14 27 0 0 0 0 % E
% Phe: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 7 % F
% Gly: 7 7 20 14 0 7 7 0 7 0 0 7 7 0 14 % G
% His: 7 0 0 7 0 0 7 7 0 0 0 0 7 0 0 % H
% Ile: 0 14 0 0 7 14 14 0 0 0 0 0 7 0 0 % I
% Lys: 0 0 0 7 0 0 0 0 7 0 0 0 0 0 0 % K
% Leu: 7 7 7 0 7 27 0 7 7 14 14 14 14 20 7 % L
% Met: 0 14 0 0 0 7 7 7 0 0 0 0 0 14 0 % M
% Asn: 0 0 0 7 14 7 27 0 0 0 0 7 0 0 14 % N
% Pro: 7 0 0 27 0 0 14 0 27 14 14 7 27 0 14 % P
% Gln: 14 0 7 7 0 14 0 7 20 0 14 0 14 14 0 % Q
% Arg: 0 0 34 7 7 0 0 0 14 0 7 34 0 0 7 % R
% Ser: 27 14 7 7 7 14 0 34 7 0 14 7 0 47 20 % S
% Thr: 0 0 0 7 7 0 7 7 14 0 0 7 7 0 0 % T
% Val: 0 7 0 7 7 0 7 0 0 34 0 7 0 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 7 0 0 0 0 0 7 0 7 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _