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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: AMFR All Species: 5.76
Human Site: S523 Identified Species: 9.05
UniProt: Q9UKV5 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UKV5 NP_001135.3 643 72996 S523 S P V E R P S S D Q E E G E T
Chimpanzee Pan troglodytes XP_001135064 580 66233 S460 S P V E R P S S D Q E E G E T
Rhesus Macaque Macaca mulatta XP_001091030 552 63193 D449 Q T E R V P L D L S P R L E E
Dog Lupus familis XP_544395 453 51620 S350 E R V P L D L S P R L E E A L
Cat Felis silvestris
Mouse Mus musculus Q9R049 643 73087 P523 S P V E R P S P D L E E G E A
Rat Rattus norvegicus Q6Y290 419 46430 P316 L K A L G I V P N L P C T D N
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_414064 763 87868 A643 S S V E R H S A D Q E D T G T
Frog Xenopus laevis Q5XHH7 595 65901 N485 A R L Q C L Q N I H T L L D A
Zebra Danio Brachydanio rerio Q803I8 625 68739 L511 T L L D A A M L N I H H Y L S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q95SP2 626 69254 A503 S Q Y Q S L S A R L Q L T A V
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P90859 564 64691 G460 M T D L R Q S G S A Q S T I E
Sea Urchin Strong. purpuratus XP_792411 845 93984 F640 A Q A P P G S F Q A F Q P N Q
Poplar Tree Populus trichocarpa XP_002303501 581 64513 R466 A G P S T A M R S V G L G G V
Maize Zea mays NP_001137060 503 56440 N400 Y P P A N T L N S R S G S P Q
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_849843 460 52108 G357 H Q E S L Q Q G T G T S S S D
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 85.2 84.5 66.5 N.A. 94.4 20.2 N.A. N.A. 69.8 20.2 23.7 N.A. 23 N.A. 21.7 40.5
Protein Similarity: 100 85.2 84.7 67.8 N.A. 96.5 34.8 N.A. N.A. 76.1 36.7 39.9 N.A. 42.6 N.A. 42.4 52.7
P-Site Identity: 100 100 13.3 20 N.A. 80 0 N.A. N.A. 60 0 0 N.A. 13.3 N.A. 13.3 6.6
P-Site Similarity: 100 100 13.3 26.6 N.A. 80 13.3 N.A. N.A. 73.3 33.3 33.3 N.A. 33.3 N.A. 20 20
Percent
Protein Identity: 23.7 24.5 N.A. 25.3 N.A. N.A.
Protein Similarity: 41.5 40.2 N.A. 40.7 N.A. N.A.
P-Site Identity: 6.6 6.6 N.A. 0 N.A. N.A.
P-Site Similarity: 13.3 20 N.A. 0 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 20 0 14 7 7 14 0 14 0 14 0 0 0 14 14 % A
% Cys: 0 0 0 0 7 0 0 0 0 0 0 7 0 0 0 % C
% Asp: 0 0 7 7 0 7 0 7 27 0 0 7 0 14 7 % D
% Glu: 7 0 14 27 0 0 0 0 0 0 27 27 7 27 14 % E
% Phe: 0 0 0 0 0 0 0 7 0 0 7 0 0 0 0 % F
% Gly: 0 7 0 0 7 7 0 14 0 7 7 7 27 14 0 % G
% His: 7 0 0 0 0 7 0 0 0 7 7 7 0 0 0 % H
% Ile: 0 0 0 0 0 7 0 0 7 7 0 0 0 7 0 % I
% Lys: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 7 7 14 14 14 14 20 7 7 20 7 20 14 7 7 % L
% Met: 7 0 0 0 0 0 14 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 7 0 0 14 14 0 0 0 0 7 7 % N
% Pro: 0 27 14 14 7 27 0 14 7 0 14 0 7 7 0 % P
% Gln: 7 20 0 14 0 14 14 0 7 20 14 7 0 0 14 % Q
% Arg: 0 14 0 7 34 0 0 7 7 14 0 7 0 0 0 % R
% Ser: 34 7 0 14 7 0 47 20 20 7 7 14 14 7 7 % S
% Thr: 7 14 0 0 7 7 0 0 7 0 14 0 27 0 20 % T
% Val: 0 0 34 0 7 0 7 0 0 7 0 0 0 0 14 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 7 0 7 0 0 0 0 0 0 0 0 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _