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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2C2
All Species:
23.64
Human Site:
S189
Identified Species:
43.33
UniProt:
Q9UKV8
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UKV8
NP_001158095.1
859
97208
S189
F
T
A
S
E
G
C
S
N
P
L
G
G
G
R
Chimpanzee
Pan troglodytes
XP_001142838
813
92351
L169
P
S
L
W
K
M
M
L
N
I
D
V
S
A
T
Rhesus Macaque
Macaca mulatta
XP_001100725
1053
117937
S381
F
T
A
S
E
G
C
S
N
P
L
G
G
G
R
Dog
Lupus familis
XP_532338
899
101246
S229
F
T
A
S
E
G
C
S
N
P
L
G
G
G
R
Cat
Felis silvestris
Mouse
Mus musculus
Q8CJG0
860
97305
S190
F
T
A
S
E
G
C
S
N
P
L
G
G
G
R
Rat
Rattus norvegicus
Q9QZ81
860
97300
S190
F
T
A
S
E
G
C
S
N
P
L
G
G
G
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513588
873
98974
S203
F
T
A
S
E
G
C
S
N
P
L
G
G
G
R
Chicken
Gallus gallus
Q5ZLG4
860
97253
D190
F
S
A
P
E
G
Y
D
H
P
L
G
G
G
R
Frog
Xenopus laevis
Q6DCX2
862
97626
A192
F
T
A
S
E
G
C
A
N
P
L
G
G
G
R
Zebra Danio
Brachydanio rerio
A3KPK0
860
97313
D190
F
S
S
P
E
G
Y
D
H
P
L
G
G
G
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUQ5
1214
136831
N563
F
K
M
S
D
P
N
N
R
H
E
L
D
D
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34681
1040
115397
Y259
Y
T
W
K
S
S
C
Y
R
I
P
T
A
A
G
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04379
1048
116172
K348
Y
S
P
D
I
G
K
K
Q
S
L
G
D
G
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.6
80.2
95.3
N.A.
98.9
99
N.A.
97.1
79.7
96.1
79.4
N.A.
22.4
N.A.
33.4
N.A.
Protein Similarity:
100
94.6
81
95.3
N.A.
99
99.3
N.A.
97.5
89.3
98.2
89.4
N.A.
36.4
N.A.
51.5
N.A.
P-Site Identity:
100
6.6
100
100
N.A.
100
100
N.A.
100
66.6
93.3
60
N.A.
13.3
N.A.
13.3
N.A.
P-Site Similarity:
100
20
100
100
N.A.
100
100
N.A.
100
80
100
80
N.A.
26.6
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
37.5
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
53.4
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
62
0
0
0
0
8
0
0
0
0
8
16
0
% A
% Cys:
0
0
0
0
0
0
62
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
8
0
0
16
0
0
8
0
16
8
0
% D
% Glu:
0
0
0
0
70
0
0
0
0
0
8
0
0
0
0
% E
% Phe:
77
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
77
0
0
0
0
0
77
70
77
16
% G
% His:
0
0
0
0
0
0
0
0
16
8
0
0
0
0
0
% H
% Ile:
0
0
0
0
8
0
0
0
0
16
0
0
0
0
0
% I
% Lys:
0
8
0
8
8
0
8
8
0
0
0
0
0
0
0
% K
% Leu:
0
0
8
0
0
0
0
8
0
0
77
8
0
0
8
% L
% Met:
0
0
8
0
0
8
8
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
8
8
62
0
0
0
0
0
0
% N
% Pro:
8
0
8
16
0
8
0
0
0
70
8
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
16
0
0
0
0
0
70
% R
% Ser:
0
31
8
62
8
8
0
47
0
8
0
0
8
0
0
% S
% Thr:
0
62
0
0
0
0
0
0
0
0
0
8
0
0
8
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% V
% Trp:
0
0
8
8
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
16
0
0
0
0
0
16
8
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _