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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2C1
All Species:
40.91
Human Site:
T509
Identified Species:
75
UniProt:
Q9UL18
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UL18
NP_036331.1
857
97214
T509
M
F
R
H
L
K
N
T
Y
S
G
L
Q
L
I
Chimpanzee
Pan troglodytes
XP_001167349
817
92830
T469
M
F
R
H
L
K
N
T
Y
S
G
L
Q
L
I
Rhesus Macaque
Macaca mulatta
XP_001100725
1053
117937
T705
M
F
R
H
L
K
N
T
Y
A
G
L
Q
L
V
Dog
Lupus familis
XP_532563
1037
115859
T689
M
F
R
H
L
K
N
T
Y
S
G
L
Q
L
I
Cat
Felis silvestris
Mouse
Mus musculus
Q8CJG1
857
97083
T509
M
F
R
H
L
K
N
T
Y
S
G
L
Q
L
I
Rat
Rattus norvegicus
Q9QZ81
860
97300
T512
M
F
R
H
L
K
N
T
Y
A
G
L
Q
L
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510209
1055
118422
T707
M
F
R
H
L
K
N
T
Y
S
G
L
Q
L
I
Chicken
Gallus gallus
Q5ZLG4
860
97253
T512
M
F
R
H
L
K
N
T
Y
S
G
L
Q
L
I
Frog
Xenopus laevis
Q6DCX2
862
97626
T514
M
F
R
H
L
K
N
T
Y
T
G
L
Q
L
V
Zebra Danio
Brachydanio rerio
A3KPK0
860
97313
T512
M
F
R
H
L
K
N
T
Y
A
G
L
Q
L
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUQ5
1214
136831
E868
Y
R
P
F
T
D
D
E
R
S
L
D
T
I
F
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34681
1040
115397
N655
A
D
E
Y
R
V
T
N
T
V
C
D
C
I
I
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04379
1048
116172
G671
A
T
S
K
L
S
Q
G
K
E
I
D
L
L
I
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.3
66.8
82.6
N.A.
99.5
82.3
N.A.
75.2
84.5
82
84.7
N.A.
23.2
N.A.
32.6
N.A.
Protein Similarity:
100
94.1
74.8
82.6
N.A.
99.7
91.2
N.A.
76.7
91.6
90.5
92
N.A.
37.1
N.A.
51.1
N.A.
P-Site Identity:
100
100
86.6
100
N.A.
100
86.6
N.A.
100
100
86.6
93.3
N.A.
6.6
N.A.
6.6
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
20
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
37.2
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52.3
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
0
0
0
0
0
0
0
0
24
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
8
0
8
0
0
% C
% Asp:
0
8
0
0
0
8
8
0
0
0
0
24
0
0
0
% D
% Glu:
0
0
8
0
0
0
0
8
0
8
0
0
0
0
0
% E
% Phe:
0
77
0
8
0
0
0
0
0
0
0
0
0
0
8
% F
% Gly:
0
0
0
0
0
0
0
8
0
0
77
0
0
0
0
% G
% His:
0
0
0
77
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
8
0
0
16
70
% I
% Lys:
0
0
0
8
0
77
0
0
8
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
85
0
0
0
0
0
8
77
8
85
0
% L
% Met:
77
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
77
8
0
0
0
0
0
0
0
% N
% Pro:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
8
0
0
0
0
0
77
0
0
% Q
% Arg:
0
8
77
0
8
0
0
0
8
0
0
0
0
0
0
% R
% Ser:
0
0
8
0
0
8
0
0
0
54
0
0
0
0
0
% S
% Thr:
0
8
0
0
8
0
8
77
8
8
0
0
8
0
0
% T
% Val:
0
0
0
0
0
8
0
0
0
8
0
0
0
0
24
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
8
0
0
0
0
77
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _