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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PYCARD
All Species:
9.09
Human Site:
S186
Identified Species:
25
UniProt:
Q9ULZ3
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9ULZ3
NP_037390.2
195
21627
S186
Q
A
L
R
E
S
Q
S
Y
L
V
E
D
L
E
Chimpanzee
Pan troglodytes
XP_001158687
195
21638
S186
Q
A
L
R
E
S
Q
S
Y
L
V
E
D
L
E
Rhesus Macaque
Macaca mulatta
XP_001112804
195
21540
S186
Q
A
L
R
E
T
Q
S
Y
L
V
E
D
L
E
Dog
Lupus familis
XP_848608
195
21781
P186
T
A
L
R
N
T
Q
P
Y
L
V
A
D
L
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9EPB4
193
21440
P184
Q
A
L
K
E
I
H
P
Y
L
V
M
D
L
E
Rat
Rattus norvegicus
NP_758825
193
21635
P184
E
A
L
R
Q
T
Q
P
Y
L
V
T
D
L
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507377
191
21323
P182
Q
A
L
K
A
T
H
P
F
L
V
S
D
L
E
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001086388
200
23168
K190
Q
Y
L
L
K
H
N
K
P
L
I
K
D
L
E
Zebra Danio
Brachydanio rerio
Q9I9N6
203
22849
N192
Y
D
A
L
R
E
S
N
K
F
L
M
D
D
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
91.7
76.9
N.A.
71.7
69.7
N.A.
58.4
N.A.
36.5
31
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.4
94.8
85.1
N.A.
81.5
80
N.A.
72.8
N.A.
56
52.2
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
93.3
66.6
N.A.
66.6
66.6
N.A.
53.3
N.A.
40
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
73.3
N.A.
73.3
86.6
N.A.
73.3
N.A.
60
20
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
78
12
0
12
0
0
0
0
0
0
12
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
12
0
0
0
0
0
0
0
0
0
0
100
12
0
% D
% Glu:
12
0
0
0
45
12
0
0
0
0
0
34
0
0
89
% E
% Phe:
0
0
0
0
0
0
0
0
12
12
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
12
23
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
12
0
0
0
0
12
0
0
0
0
% I
% Lys:
0
0
0
23
12
0
0
12
12
0
0
12
0
0
0
% K
% Leu:
0
0
89
23
0
0
0
0
0
89
12
0
0
89
12
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
23
0
0
0
% M
% Asn:
0
0
0
0
12
0
12
12
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
45
12
0
0
0
0
0
0
% P
% Gln:
67
0
0
0
12
0
56
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
56
12
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
23
12
34
0
0
0
12
0
0
0
% S
% Thr:
12
0
0
0
0
45
0
0
0
0
0
12
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
78
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
12
12
0
0
0
0
0
0
67
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _