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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NOTCH3 All Species: 0.91
Human Site: S1688 Identified Species: 1.67
UniProt: Q9UM47 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.33
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UM47 NP_000426.2 2321 243659 S1688 S L H K D V A S G H K G R R E
Chimpanzee Pan troglodytes XP_520371 2555 272693 K1781 K V S E A S K K K R R E P L G
Rhesus Macaque Macaca mulatta XP_001114248 2471 265649 N1723 T L R R D A S N H K R R E P V
Dog Lupus familis XP_853041 2129 224888 A1737 A L H K D V A A G H K G R R E
Cat Felis silvestris
Mouse Mus musculus Q61982 2318 244229 A1689 A L H K D I A A G H K G R R E
Rat Rattus norvegicus Q9R172 2319 244282 A1690 A L H K D I A A G H K G R R E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512292 2467 261963 N1719 V L R R D S S N H K R R E P V
Chicken Gallus gallus XP_415420 2590 279561 K1819 K V T E S S K K K R R E P L G
Frog Xenopus laevis P21783 2524 275106 K1775 I P K E P S K K K R R D R L G
Zebra Danio Brachydanio rerio P46530 2437 262289 K1772 K V N E P K K K R R E P V G E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P07207 2703 288835 S1789 R A P A A V M S R R R R D P H
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P14585 1429 157097 N999 P N P Q G Y G N G N D F L G D
Sea Urchin Strong. purpuratus P10079 1064 112055 V695 R V D S Y E C V C A A G Y T A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 48.9 49.4 77.9 N.A. 90.9 91.4 N.A. 49.4 47.4 47 48.3 N.A. 39.7 N.A. 21.9 21.9
Protein Similarity: 100 62 63 80.9 N.A. 93.8 94 N.A. 61.6 61.2 61.5 62.2 N.A. 52.8 N.A. 33.3 30.5
P-Site Identity: 100 0 13.3 86.6 N.A. 80 80 N.A. 13.3 0 6.6 6.6 N.A. 13.3 N.A. 6.6 6.6
P-Site Similarity: 100 20 46.6 100 N.A. 100 100 N.A. 40 20 20 33.3 N.A. 20 N.A. 33.3 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 24 8 0 8 16 8 31 24 0 8 8 0 0 0 8 % A
% Cys: 0 0 0 0 0 0 8 0 8 0 0 0 0 0 0 % C
% Asp: 0 0 8 0 47 0 0 0 0 0 8 8 8 0 8 % D
% Glu: 0 0 0 31 0 8 0 0 0 0 8 16 16 0 39 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % F
% Gly: 0 0 0 0 8 0 8 0 39 0 0 39 0 16 24 % G
% His: 0 0 31 0 0 0 0 0 16 31 0 0 0 0 8 % H
% Ile: 8 0 0 0 0 16 0 0 0 0 0 0 0 0 0 % I
% Lys: 24 0 8 31 0 8 31 31 24 16 31 0 0 0 0 % K
% Leu: 0 47 0 0 0 0 0 0 0 0 0 0 8 24 0 % L
% Met: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % M
% Asn: 0 8 8 0 0 0 0 24 0 8 0 0 0 0 0 % N
% Pro: 8 8 16 0 16 0 0 0 0 0 0 8 16 24 0 % P
% Gln: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 16 0 16 16 0 0 0 0 16 39 47 24 39 31 0 % R
% Ser: 8 0 8 8 8 31 16 16 0 0 0 0 0 0 0 % S
% Thr: 8 0 8 0 0 0 0 0 0 0 0 0 0 8 0 % T
% Val: 8 31 0 0 0 24 0 8 0 0 0 0 8 0 16 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 8 8 0 0 0 0 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _