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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH3
All Species:
23.03
Human Site:
S1817
Identified Species:
42.22
UniProt:
Q9UM47
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UM47
NP_000426.2
2321
243659
S1817
E
D
E
A
D
D
T
S
A
S
I
I
S
D
L
Chimpanzee
Pan troglodytes
XP_520371
2555
272693
A1906
N
S
E
E
E
E
D
A
P
A
V
I
S
D
F
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
S1855
D
E
D
A
E
D
S
S
A
N
I
I
T
D
L
Dog
Lupus familis
XP_853041
2129
224888
E1791
E
E
P
S
V
G
A
E
D
A
V
D
C
R
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q61982
2318
244229
S1818
E
D
E
A
D
D
T
S
A
S
I
I
S
D
L
Rat
Rattus norvegicus
Q9R172
2319
244282
S1819
E
D
E
A
D
D
T
S
A
S
I
I
S
D
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
P1851
D
D
E
A
E
D
S
P
A
N
I
I
T
D
L
Chicken
Gallus gallus
XP_415420
2590
279561
A1945
N
S
E
E
E
D
D
A
P
A
V
I
S
D
F
Frog
Xenopus laevis
P21783
2524
275106
S1903
S
E
E
E
E
D
A
S
A
N
M
I
S
D
F
Zebra Danio
Brachydanio rerio
P46530
2437
262289
S1894
G
E
A
E
E
D
P
S
A
D
V
I
T
D
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
T1929
I
E
N
N
E
D
S
T
A
Q
V
I
S
D
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
I1048
T
R
E
S
V
N
I
I
D
P
R
H
N
R
T
Sea Urchin
Strong. purpuratus
P10079
1064
112055
G740
N
C
A
P
G
Y
T
G
D
N
C
E
T
E
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
48.9
49.4
77.9
N.A.
90.9
91.4
N.A.
49.4
47.4
47
48.3
N.A.
39.7
N.A.
21.9
21.9
Protein Similarity:
100
62
63
80.9
N.A.
93.8
94
N.A.
61.6
61.2
61.5
62.2
N.A.
52.8
N.A.
33.3
30.5
P-Site Identity:
100
26.6
53.3
6.6
N.A.
100
100
N.A.
60
33.3
46.6
33.3
N.A.
40
N.A.
6.6
6.6
P-Site Similarity:
100
60
100
33.3
N.A.
100
100
N.A.
93.3
60
73.3
60
N.A.
73.3
N.A.
26.6
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
16
39
0
0
16
16
62
24
0
0
0
0
0
% A
% Cys:
0
8
0
0
0
0
0
0
0
0
8
0
8
0
0
% C
% Asp:
16
31
8
0
24
70
16
0
24
8
0
8
0
77
0
% D
% Glu:
31
39
62
31
54
8
0
8
0
0
0
8
0
8
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
31
% F
% Gly:
8
0
0
0
8
8
0
8
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% H
% Ile:
8
0
0
0
0
0
8
8
0
0
39
77
0
0
8
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
47
% L
% Met:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% M
% Asn:
24
0
8
8
0
8
0
0
0
31
0
0
8
0
0
% N
% Pro:
0
0
8
8
0
0
8
8
16
8
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
8
% Q
% Arg:
0
8
0
0
0
0
0
0
0
0
8
0
0
16
0
% R
% Ser:
8
16
0
16
0
0
24
47
0
24
0
0
54
0
0
% S
% Thr:
8
0
0
0
0
0
31
8
0
0
0
0
31
0
8
% T
% Val:
0
0
0
0
16
0
0
0
0
0
39
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _