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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH3
All Species:
9.09
Human Site:
S1970
Identified Species:
16.67
UniProt:
Q9UM47
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UM47
NP_000426.2
2321
243659
S1970
A
N
K
D
M
Q
D
S
K
E
E
T
P
L
F
Chimpanzee
Pan troglodytes
XP_520371
2555
272693
N2059
A
N
K
D
M
Q
N
N
R
E
E
T
P
L
F
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
N2008
A
N
R
D
M
Q
D
N
K
E
E
T
P
L
F
Dog
Lupus familis
XP_853041
2129
224888
R1886
Q
L
G
A
R
T
D
R
T
G
E
T
A
L
H
Cat
Felis silvestris
Mouse
Mus musculus
Q61982
2318
244229
S1971
A
N
K
D
M
Q
D
S
K
E
E
T
P
L
F
Rat
Rattus norvegicus
Q9R172
2319
244282
S1972
A
N
K
D
M
Q
D
S
K
E
E
T
P
L
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
N2004
A
N
R
D
M
Q
D
N
K
E
E
T
P
L
F
Chicken
Gallus gallus
XP_415420
2590
279561
N2098
A
N
K
D
M
Q
N
N
K
E
E
T
P
L
F
Frog
Xenopus laevis
P21783
2524
275106
N2056
A
N
K
D
M
Q
N
N
K
E
E
T
S
L
F
Zebra Danio
Brachydanio rerio
P46530
2437
262289
N2047
A
N
K
D
L
Q
N
N
K
E
E
T
P
L
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
D2082
A
N
R
D
A
Q
D
D
K
D
E
T
P
L
F
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
N1162
D
I
E
E
L
D
R
N
G
M
T
A
L
M
I
Sea Urchin
Strong. purpuratus
P10079
1064
112055
D829
N
I
D
E
C
A
S
D
P
C
L
N
G
G
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
48.9
49.4
77.9
N.A.
90.9
91.4
N.A.
49.4
47.4
47
48.3
N.A.
39.7
N.A.
21.9
21.9
Protein Similarity:
100
62
63
80.9
N.A.
93.8
94
N.A.
61.6
61.2
61.5
62.2
N.A.
52.8
N.A.
33.3
30.5
P-Site Identity:
100
80
86.6
26.6
N.A.
100
100
N.A.
86.6
86.6
80
80
N.A.
73.3
N.A.
0
0
P-Site Similarity:
100
100
100
26.6
N.A.
100
100
N.A.
100
100
93.3
100
N.A.
86.6
N.A.
33.3
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
77
0
0
8
8
8
0
0
0
0
0
8
8
0
0
% A
% Cys:
0
0
0
0
8
0
0
0
0
8
0
0
0
0
0
% C
% Asp:
8
0
8
77
0
8
54
16
0
8
0
0
0
0
0
% D
% Glu:
0
0
8
16
0
0
0
0
0
70
85
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
77
% F
% Gly:
0
0
8
0
0
0
0
0
8
8
0
0
8
8
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% H
% Ile:
0
16
0
0
0
0
0
0
0
0
0
0
0
0
16
% I
% Lys:
0
0
54
0
0
0
0
0
70
0
0
0
0
0
0
% K
% Leu:
0
8
0
0
16
0
0
0
0
0
8
0
8
85
0
% L
% Met:
0
0
0
0
62
0
0
0
0
8
0
0
0
8
0
% M
% Asn:
8
77
0
0
0
0
31
54
0
0
0
8
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
8
0
0
0
70
0
0
% P
% Gln:
8
0
0
0
0
77
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
24
0
8
0
8
8
8
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
8
24
0
0
0
0
8
0
0
% S
% Thr:
0
0
0
0
0
8
0
0
8
0
8
85
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _