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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH3
All Species:
22.73
Human Site:
S2032
Identified Species:
41.67
UniProt:
Q9UM47
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UM47
NP_000426.2
2321
243659
S2032
D
Q
P
S
G
P
R
S
P
P
G
P
H
G
L
Chimpanzee
Pan troglodytes
XP_520371
2555
272693
S2121
D
E
Y
N
L
V
R
S
P
Q
L
H
G
A
P
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
S2070
D
E
Y
N
V
T
P
S
P
P
G
T
V
L
T
Dog
Lupus familis
XP_853041
2129
224888
S1920
D
T
N
A
Q
D
H
S
G
R
T
P
L
H
T
Cat
Felis silvestris
Mouse
Mus musculus
Q61982
2318
244229
S2033
D
Q
P
S
G
P
R
S
P
S
G
P
H
G
L
Rat
Rattus norvegicus
Q9R172
2319
244282
S2034
D
Q
P
S
G
P
R
S
P
S
G
P
H
G
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
S2066
S
E
Y
N
V
A
H
S
P
P
G
T
V
L
A
Chicken
Gallus gallus
XP_415420
2590
279561
S2160
D
E
Y
N
L
V
R
S
P
P
L
H
S
G
P
Frog
Xenopus laevis
P21783
2524
275106
S2118
D
E
Y
N
L
V
K
S
P
T
L
H
N
G
P
Zebra Danio
Brachydanio rerio
P46530
2437
262289
S2109
E
E
Y
N
L
V
R
S
P
P
L
P
L
S
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
A2176
T
Q
P
T
V
I
S
A
G
N
G
G
N
N
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
A1197
A
K
V
D
Y
D
G
A
A
R
K
D
S
E
K
Sea Urchin
Strong. purpuratus
P10079
1064
112055
D862
T
Y
C
E
I
S
L
D
A
C
R
S
M
P
C
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
48.9
49.4
77.9
N.A.
90.9
91.4
N.A.
49.4
47.4
47
48.3
N.A.
39.7
N.A.
21.9
21.9
Protein Similarity:
100
62
63
80.9
N.A.
93.8
94
N.A.
61.6
61.2
61.5
62.2
N.A.
52.8
N.A.
33.3
30.5
P-Site Identity:
100
26.6
33.3
20
N.A.
93.3
93.3
N.A.
26.6
40
26.6
33.3
N.A.
20
N.A.
0
0
P-Site Similarity:
100
40
46.6
26.6
N.A.
93.3
93.3
N.A.
40
53.3
53.3
53.3
N.A.
40
N.A.
13.3
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
8
0
8
0
16
16
0
0
0
0
8
8
% A
% Cys:
0
0
8
0
0
0
0
0
0
8
0
0
0
0
8
% C
% Asp:
62
0
0
8
0
16
0
8
0
0
0
8
0
0
0
% D
% Glu:
8
47
0
8
0
0
0
0
0
0
0
0
0
8
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
24
0
8
0
16
0
47
8
8
39
8
% G
% His:
0
0
0
0
0
0
16
0
0
0
0
24
24
8
0
% H
% Ile:
0
0
0
0
8
8
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
8
0
0
0
0
8
0
0
0
8
0
0
0
8
% K
% Leu:
0
0
0
0
31
0
8
0
0
0
31
0
16
16
24
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% M
% Asn:
0
0
8
47
0
0
0
0
0
8
0
0
16
8
0
% N
% Pro:
0
0
31
0
0
24
8
0
70
39
0
39
0
8
31
% P
% Gln:
0
31
0
0
8
0
0
0
0
8
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
47
0
0
16
8
0
0
0
0
% R
% Ser:
8
0
0
24
0
8
8
77
0
16
0
8
16
8
0
% S
% Thr:
16
8
0
8
0
8
0
0
0
8
8
16
0
0
16
% T
% Val:
0
0
8
0
24
31
0
0
0
0
0
0
16
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
47
0
8
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _