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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH3
All Species:
12.73
Human Site:
S2063
Identified Species:
23.33
UniProt:
Q9UM47
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UM47
NP_000426.2
2321
243659
S2063
A
Q
S
G
S
K
K
S
R
R
P
P
G
K
A
Chimpanzee
Pan troglodytes
XP_520371
2555
272693
A2173
L
A
C
G
S
K
E
A
K
D
L
K
A
R
R
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
N2110
S
R
R
P
S
A
K
N
T
M
P
T
S
L
P
Dog
Lupus familis
XP_853041
2129
224888
L1940
A
Q
G
V
F
Q
I
L
I
R
N
R
S
T
D
Cat
Felis silvestris
Mouse
Mus musculus
Q61982
2318
244229
S2064
V
Q
S
G
T
K
K
S
R
R
P
P
G
K
T
Rat
Rattus norvegicus
Q9R172
2319
244282
S2065
V
Q
S
G
T
K
K
S
R
R
P
P
G
K
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
P2120
L
P
N
L
A
R
E
P
K
D
P
R
S
G
G
Chicken
Gallus gallus
XP_415420
2590
279561
A2196
P
A
V
Q
G
K
K
A
R
K
P
S
T
K
G
Frog
Xenopus laevis
P21783
2524
275106
A2154
P
S
V
Q
S
K
K
A
R
K
P
S
I
K
G
Zebra Danio
Brachydanio rerio
P46530
2437
262289
T2141
N
N
N
T
A
K
K
T
R
K
P
G
G
K
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
A2200
N
Q
T
A
K
Q
K
A
A
K
K
A
K
L
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
S1218
L
H
Y
A
A
Q
V
S
N
M
P
I
V
K
Y
Sea Urchin
Strong. purpuratus
P10079
1064
112055
Y882
C
V
N
V
G
A
D
Y
V
C
E
C
V
P
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
48.9
49.4
77.9
N.A.
90.9
91.4
N.A.
49.4
47.4
47
48.3
N.A.
39.7
N.A.
21.9
21.9
Protein Similarity:
100
62
63
80.9
N.A.
93.8
94
N.A.
61.6
61.2
61.5
62.2
N.A.
52.8
N.A.
33.3
30.5
P-Site Identity:
100
20
20
20
N.A.
80
80
N.A.
6.6
33.3
40
40
N.A.
13.3
N.A.
20
0
P-Site Similarity:
100
46.6
40
26.6
N.A.
86.6
86.6
N.A.
40
46.6
53.3
66.6
N.A.
40
N.A.
33.3
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
16
0
16
24
16
0
31
8
0
0
8
8
0
8
% A
% Cys:
8
0
8
0
0
0
0
0
0
8
0
8
0
0
0
% C
% Asp:
0
0
0
0
0
0
8
0
0
16
0
0
0
0
8
% D
% Glu:
0
0
0
0
0
0
16
0
0
0
8
0
0
0
0
% E
% Phe:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
8
31
16
0
0
0
0
0
0
8
31
8
39
% G
% His:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
8
0
8
0
0
8
8
0
8
% I
% Lys:
0
0
0
0
8
54
62
0
16
31
8
8
8
54
0
% K
% Leu:
24
0
0
8
0
0
0
8
0
0
8
0
0
16
0
% L
% Met:
0
0
0
0
0
0
0
0
0
16
0
0
0
0
0
% M
% Asn:
16
8
24
0
0
0
0
8
8
0
8
0
0
0
0
% N
% Pro:
16
8
0
8
0
0
0
8
0
0
70
24
0
8
8
% P
% Gln:
0
39
0
16
0
24
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
8
8
0
0
8
0
0
47
31
0
16
0
8
8
% R
% Ser:
8
8
24
0
31
0
0
31
0
0
0
16
24
0
0
% S
% Thr:
0
0
8
8
16
0
0
8
8
0
0
8
8
8
16
% T
% Val:
16
8
16
16
0
0
8
0
8
0
0
0
16
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
8
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _