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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NOTCH3 All Species: 30
Human Site: S2104 Identified Species: 55
UniProt: Q9UM47 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UM47 NP_000426.2 2321 243659 S2104 V T L S P V D S L D S P R P F
Chimpanzee Pan troglodytes XP_520371 2555 272693 S2202 G M L S P V D S L E S P H G Y
Rhesus Macaque Macaca mulatta XP_001114248 2471 265649 S2153 V T L S P V D S L E S P H T Y
Dog Lupus familis XP_853041 2129 224888 A1966 L I L A A R L A V E G M V E E
Cat Felis silvestris
Mouse Mus musculus Q61982 2318 244229 S2105 V T L S P V D S L D S P R P F
Rat Rattus norvegicus Q9R172 2319 244282 S2106 V T L S P V D S L D S P R P F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512292 2467 261963 S2151 V T L S P V D S L E S P H A Y
Chicken Gallus gallus XP_415420 2590 279561 S2240 S V L S P V D S L E S P H G Y
Frog Xenopus laevis P21783 2524 275106 S2198 G V L S P V D S L E S T H G Y
Zebra Danio Brachydanio rerio P46530 2437 262289 S2184 G V L S P V D S L E S P H G Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P07207 2703 288835 G2242 K K A A N L N G L N P G Q L T
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P14585 1429 157097 A1248 G K T P I M L A A Q E G R I E
Sea Urchin Strong. purpuratus P10079 1064 112055 P906 I N E C A S L P C Q N G G L C
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 48.9 49.4 77.9 N.A. 90.9 91.4 N.A. 49.4 47.4 47 48.3 N.A. 39.7 N.A. 21.9 21.9
Protein Similarity: 100 62 63 80.9 N.A. 93.8 94 N.A. 61.6 61.2 61.5 62.2 N.A. 52.8 N.A. 33.3 30.5
P-Site Identity: 100 60 73.3 6.6 N.A. 100 100 N.A. 73.3 60 53.3 60 N.A. 6.6 N.A. 6.6 0
P-Site Similarity: 100 73.3 86.6 40 N.A. 100 100 N.A. 86.6 73.3 66.6 73.3 N.A. 40 N.A. 20 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 16 16 0 0 16 8 0 0 0 0 8 0 % A
% Cys: 0 0 0 8 0 0 0 0 8 0 0 0 0 0 8 % C
% Asp: 0 0 0 0 0 0 70 0 0 24 0 0 0 0 0 % D
% Glu: 0 0 8 0 0 0 0 0 0 54 8 0 0 8 16 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 24 % F
% Gly: 31 0 0 0 0 0 0 8 0 0 8 24 8 31 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 47 0 0 % H
% Ile: 8 8 0 0 8 0 0 0 0 0 0 0 0 8 0 % I
% Lys: 8 16 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 8 0 77 0 0 8 24 0 77 0 0 0 0 16 0 % L
% Met: 0 8 0 0 0 8 0 0 0 0 0 8 0 0 0 % M
% Asn: 0 8 0 0 8 0 8 0 0 8 8 0 0 0 0 % N
% Pro: 0 0 0 8 70 0 0 8 0 0 8 62 0 24 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 16 0 0 8 0 0 % Q
% Arg: 0 0 0 0 0 8 0 0 0 0 0 0 31 0 0 % R
% Ser: 8 0 0 70 0 8 0 70 0 0 70 0 0 0 0 % S
% Thr: 0 39 8 0 0 0 0 0 0 0 0 8 0 8 8 % T
% Val: 39 24 0 0 0 70 0 0 8 0 0 0 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 47 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _