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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH3
All Species:
14.55
Human Site:
S2117
Identified Species:
26.67
UniProt:
Q9UM47
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UM47
NP_000426.2
2321
243659
S2117
P
F
G
G
P
P
A
S
P
G
G
F
P
L
E
Chimpanzee
Pan troglodytes
XP_520371
2555
272693
S2215
G
Y
L
S
D
V
A
S
P
P
L
L
P
S
P
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
S2166
T
Y
V
S
D
T
T
S
S
P
M
I
T
S
P
Dog
Lupus familis
XP_853041
2129
224888
A1979
E
E
L
I
A
S
H
A
D
V
N
A
V
D
E
Cat
Felis silvestris
Mouse
Mus musculus
Q61982
2318
244229
S2118
P
F
S
G
P
P
A
S
P
G
G
F
P
L
E
Rat
Rattus norvegicus
Q9R172
2319
244282
S2119
P
F
G
G
P
P
A
S
P
G
G
F
P
L
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
P2164
A
Y
G
S
D
A
T
P
S
P
M
I
T
S
P
Chicken
Gallus gallus
XP_415420
2590
279561
S2253
G
Y
L
S
D
V
A
S
P
P
L
M
T
S
P
Frog
Xenopus laevis
P21783
2524
275106
S2211
G
Y
L
S
D
V
S
S
P
P
L
M
T
S
P
Zebra Danio
Brachydanio rerio
P46530
2437
262289
S2197
G
Y
L
S
D
V
S
S
P
P
M
M
T
S
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
V2255
L
T
G
G
V
S
G
V
P
G
V
P
P
T
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
I1261
I
E
V
V
M
Y
L
I
Q
Q
G
A
S
V
E
Sea Urchin
Strong. purpuratus
P10079
1064
112055
G919
L
C
I
D
G
I
A
G
Y
T
C
Q
C
R
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
48.9
49.4
77.9
N.A.
90.9
91.4
N.A.
49.4
47.4
47
48.3
N.A.
39.7
N.A.
21.9
21.9
Protein Similarity:
100
62
63
80.9
N.A.
93.8
94
N.A.
61.6
61.2
61.5
62.2
N.A.
52.8
N.A.
33.3
30.5
P-Site Identity:
100
26.6
6.6
6.6
N.A.
93.3
100
N.A.
6.6
20
13.3
13.3
N.A.
33.3
N.A.
13.3
6.6
P-Site Similarity:
100
33.3
13.3
13.3
N.A.
93.3
100
N.A.
13.3
26.6
26.6
26.6
N.A.
33.3
N.A.
20
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
8
8
47
8
0
0
0
16
0
0
0
% A
% Cys:
0
8
0
0
0
0
0
0
0
0
8
0
8
0
0
% C
% Asp:
0
0
0
8
47
0
0
0
8
0
0
0
0
8
0
% D
% Glu:
8
16
0
0
0
0
0
0
0
0
0
0
0
0
39
% E
% Phe:
0
24
0
0
0
0
0
0
0
0
0
24
0
0
0
% F
% Gly:
31
0
31
31
8
0
8
8
0
31
31
0
0
0
0
% G
% His:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
8
8
0
8
0
8
0
0
0
16
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
16
0
39
0
0
0
8
0
0
0
24
8
0
24
8
% L
% Met:
0
0
0
0
8
0
0
0
0
0
24
24
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
8
% N
% Pro:
24
0
0
0
24
24
0
8
62
47
0
8
39
0
47
% P
% Gln:
0
0
0
0
0
0
0
0
8
8
0
8
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% R
% Ser:
0
0
8
47
0
16
16
62
16
0
0
0
8
47
0
% S
% Thr:
8
8
0
0
0
8
16
0
0
8
0
0
39
8
0
% T
% Val:
0
0
16
8
8
31
0
8
0
8
8
0
8
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
47
0
0
0
8
0
0
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _