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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH3
All Species:
12.12
Human Site:
S2203
Identified Species:
22.22
UniProt:
Q9UM47
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UM47
NP_000426.2
2321
243659
S2203
L
N
P
G
T
P
V
S
P
Q
E
R
P
P
P
Chimpanzee
Pan troglodytes
XP_520371
2555
272693
L2457
S
L
A
V
H
T
I
L
P
Q
E
S
P
A
L
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
M2358
V
A
F
P
T
A
M
M
P
Q
Q
D
G
Q
V
Dog
Lupus familis
XP_853041
2129
224888
H2043
A
A
K
L
L
L
D
H
F
A
N
R
E
I
T
Cat
Felis silvestris
Mouse
Mus musculus
Q61982
2318
244229
S2203
L
N
P
G
A
P
V
S
P
Q
E
R
P
P
P
Rat
Rattus norvegicus
Q9R172
2319
244282
S2204
L
N
P
A
T
P
V
S
P
H
E
R
P
P
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
L2353
V
A
Y
P
A
A
V
L
P
Q
Q
D
G
P
A
Chicken
Gallus gallus
XP_415420
2590
279561
A2325
P
S
T
A
M
S
N
A
P
M
N
F
S
V
G
Frog
Xenopus laevis
P21783
2524
275106
T2346
L
H
N
G
L
P
A
T
T
L
S
Q
M
M
T
Zebra Danio
Brachydanio rerio
P46530
2437
262289
A2344
L
Q
S
S
S
G
H
A
P
I
Q
T
I
L
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
S2593
G
S
P
D
S
F
H
S
G
Q
M
N
P
P
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
A1323
P
S
R
K
V
T
R
A
P
K
K
Q
T
S
R
Sea Urchin
Strong. purpuratus
P10079
1064
112055
A979
E
R
A
L
G
Y
A
A
P
T
V
V
V
G
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
48.9
49.4
77.9
N.A.
90.9
91.4
N.A.
49.4
47.4
47
48.3
N.A.
39.7
N.A.
21.9
21.9
Protein Similarity:
100
62
63
80.9
N.A.
93.8
94
N.A.
61.6
61.2
61.5
62.2
N.A.
52.8
N.A.
33.3
30.5
P-Site Identity:
100
26.6
20
6.6
N.A.
93.3
86.6
N.A.
26.6
6.6
20
20
N.A.
33.3
N.A.
6.6
6.6
P-Site Similarity:
100
33.3
40
6.6
N.A.
93.3
86.6
N.A.
40
20
40
40
N.A.
46.6
N.A.
40
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
24
16
16
16
16
16
31
0
8
0
0
0
8
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
0
8
0
0
0
0
16
0
0
0
% D
% Glu:
8
0
0
0
0
0
0
0
0
0
31
0
8
0
0
% E
% Phe:
0
0
8
0
0
8
0
0
8
0
0
8
0
0
0
% F
% Gly:
8
0
0
24
8
8
0
0
8
0
0
0
16
8
8
% G
% His:
0
8
0
0
8
0
16
8
0
8
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
8
0
0
8
0
0
8
8
0
% I
% Lys:
0
0
8
8
0
0
0
0
0
8
8
0
0
0
0
% K
% Leu:
39
8
0
16
16
8
0
16
0
8
0
0
0
8
8
% L
% Met:
0
0
0
0
8
0
8
8
0
8
8
0
8
8
0
% M
% Asn:
0
24
8
0
0
0
8
0
0
0
16
8
0
0
0
% N
% Pro:
16
0
31
16
0
31
0
0
77
0
0
0
39
39
31
% P
% Gln:
0
8
0
0
0
0
0
0
0
47
24
16
0
8
0
% Q
% Arg:
0
8
8
0
0
0
8
0
0
0
0
31
0
0
8
% R
% Ser:
8
24
8
8
16
8
0
31
0
0
8
8
8
8
8
% S
% Thr:
0
0
8
0
24
16
0
8
8
8
0
8
8
0
16
% T
% Val:
16
0
0
8
8
0
31
0
0
0
8
8
8
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
8
0
0
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _