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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NOTCH3 All Species: 12.12
Human Site: S2203 Identified Species: 22.22
UniProt: Q9UM47 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UM47 NP_000426.2 2321 243659 S2203 L N P G T P V S P Q E R P P P
Chimpanzee Pan troglodytes XP_520371 2555 272693 L2457 S L A V H T I L P Q E S P A L
Rhesus Macaque Macaca mulatta XP_001114248 2471 265649 M2358 V A F P T A M M P Q Q D G Q V
Dog Lupus familis XP_853041 2129 224888 H2043 A A K L L L D H F A N R E I T
Cat Felis silvestris
Mouse Mus musculus Q61982 2318 244229 S2203 L N P G A P V S P Q E R P P P
Rat Rattus norvegicus Q9R172 2319 244282 S2204 L N P A T P V S P H E R P P P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512292 2467 261963 L2353 V A Y P A A V L P Q Q D G P A
Chicken Gallus gallus XP_415420 2590 279561 A2325 P S T A M S N A P M N F S V G
Frog Xenopus laevis P21783 2524 275106 T2346 L H N G L P A T T L S Q M M T
Zebra Danio Brachydanio rerio P46530 2437 262289 A2344 L Q S S S G H A P I Q T I L P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P07207 2703 288835 S2593 G S P D S F H S G Q M N P P S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P14585 1429 157097 A1323 P S R K V T R A P K K Q T S R
Sea Urchin Strong. purpuratus P10079 1064 112055 A979 E R A L G Y A A P T V V V G Y
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 48.9 49.4 77.9 N.A. 90.9 91.4 N.A. 49.4 47.4 47 48.3 N.A. 39.7 N.A. 21.9 21.9
Protein Similarity: 100 62 63 80.9 N.A. 93.8 94 N.A. 61.6 61.2 61.5 62.2 N.A. 52.8 N.A. 33.3 30.5
P-Site Identity: 100 26.6 20 6.6 N.A. 93.3 86.6 N.A. 26.6 6.6 20 20 N.A. 33.3 N.A. 6.6 6.6
P-Site Similarity: 100 33.3 40 6.6 N.A. 93.3 86.6 N.A. 40 20 40 40 N.A. 46.6 N.A. 40 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 24 16 16 16 16 16 31 0 8 0 0 0 8 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 8 0 0 8 0 0 0 0 16 0 0 0 % D
% Glu: 8 0 0 0 0 0 0 0 0 0 31 0 8 0 0 % E
% Phe: 0 0 8 0 0 8 0 0 8 0 0 8 0 0 0 % F
% Gly: 8 0 0 24 8 8 0 0 8 0 0 0 16 8 8 % G
% His: 0 8 0 0 8 0 16 8 0 8 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 8 0 0 8 0 0 8 8 0 % I
% Lys: 0 0 8 8 0 0 0 0 0 8 8 0 0 0 0 % K
% Leu: 39 8 0 16 16 8 0 16 0 8 0 0 0 8 8 % L
% Met: 0 0 0 0 8 0 8 8 0 8 8 0 8 8 0 % M
% Asn: 0 24 8 0 0 0 8 0 0 0 16 8 0 0 0 % N
% Pro: 16 0 31 16 0 31 0 0 77 0 0 0 39 39 31 % P
% Gln: 0 8 0 0 0 0 0 0 0 47 24 16 0 8 0 % Q
% Arg: 0 8 8 0 0 0 8 0 0 0 0 31 0 0 8 % R
% Ser: 8 24 8 8 16 8 0 31 0 0 8 8 8 8 8 % S
% Thr: 0 0 8 0 24 16 0 8 8 8 0 8 8 0 16 % T
% Val: 16 0 0 8 8 0 31 0 0 0 8 8 8 8 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 0 0 8 0 0 0 0 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _