KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH3
All Species:
20
Human Site:
S2259
Identified Species:
36.67
UniProt:
Q9UM47
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UM47
NP_000426.2
2321
243659
S2259
P
E
H
W
A
S
P
S
P
P
S
L
S
D
W
Chimpanzee
Pan troglodytes
XP_520371
2555
272693
P2505
P
S
H
Q
L
Q
V
P
E
H
P
F
L
T
P
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
S2429
P
D
Q
W
S
S
S
S
P
H
S
A
S
D
W
Dog
Lupus familis
XP_853041
2129
224888
G2089
P
H
G
P
H
G
L
G
P
L
L
C
P
P
G
Cat
Felis silvestris
Mouse
Mus musculus
Q61982
2318
244229
S2259
P
E
H
W
A
S
P
S
P
P
S
L
S
D
W
Rat
Rattus norvegicus
Q9R172
2319
244282
S2260
P
E
H
W
A
S
P
S
P
P
S
L
S
D
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
S2424
P
D
Q
W
S
S
S
S
P
H
S
A
S
D
W
Chicken
Gallus gallus
XP_415420
2590
279561
N2373
G
T
H
Q
Q
A
Q
N
L
Q
H
G
M
M
S
Frog
Xenopus laevis
P21783
2524
275106
P2474
P
S
H
Q
L
Q
V
P
D
H
P
F
L
T
P
Zebra Danio
Brachydanio rerio
P46530
2437
262289
D2390
P
N
H
Q
Q
V
P
D
H
P
F
L
T
P
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
T2641
S
Q
H
S
G
G
H
T
P
Q
H
L
V
Q
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
T1369
F
M
N
T
T
H
T
T
P
T
S
L
N
Y
L
Sea Urchin
Strong. purpuratus
P10079
1064
112055
Y1025
C
D
G
E
E
V
L
Y
T
T
W
I
N
T
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
48.9
49.4
77.9
N.A.
90.9
91.4
N.A.
49.4
47.4
47
48.3
N.A.
39.7
N.A.
21.9
21.9
Protein Similarity:
100
62
63
80.9
N.A.
93.8
94
N.A.
61.6
61.2
61.5
62.2
N.A.
52.8
N.A.
33.3
30.5
P-Site Identity:
100
13.3
60
13.3
N.A.
100
100
N.A.
60
6.6
13.3
33.3
N.A.
20
N.A.
20
0
P-Site Similarity:
100
13.3
73.3
13.3
N.A.
100
100
N.A.
73.3
20
13.3
40
N.A.
33.3
N.A.
40
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
24
8
0
0
0
0
0
16
0
0
0
% A
% Cys:
8
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% C
% Asp:
0
24
0
0
0
0
0
8
8
0
0
0
0
39
0
% D
% Glu:
0
24
0
8
8
0
0
0
8
0
0
0
0
0
0
% E
% Phe:
8
0
0
0
0
0
0
0
0
0
8
16
0
0
0
% F
% Gly:
8
0
16
0
8
16
0
8
0
0
0
8
0
0
8
% G
% His:
0
8
62
0
8
8
8
0
8
31
16
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
16
0
16
0
8
8
8
47
16
0
8
% L
% Met:
0
8
0
0
0
0
0
0
0
0
0
0
8
8
0
% M
% Asn:
0
8
8
0
0
0
0
8
0
0
0
0
16
0
8
% N
% Pro:
70
0
0
8
0
0
31
16
62
31
16
0
8
16
16
% P
% Gln:
0
8
16
31
16
16
8
0
0
16
0
0
0
8
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
8
16
0
8
16
39
16
39
0
0
47
0
39
0
16
% S
% Thr:
0
8
0
8
8
0
8
16
8
16
0
0
8
24
8
% T
% Val:
0
0
0
0
0
16
16
0
0
0
0
0
8
0
0
% V
% Trp:
0
0
0
39
0
0
0
0
0
0
8
0
0
0
39
% W
% Tyr:
0
0
0
0
0
0
0
8
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _