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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NOTCH3 All Species: 11.52
Human Site: S2299 Identified Species: 21.11
UniProt: Q9UM47 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UM47 NP_000426.2 2321 243659 S2299 L P L S V P S S L A Q A Q T Q
Chimpanzee Pan troglodytes XP_520371 2555 272693 T2541 E G V S S P P T S M Q S Q I A
Rhesus Macaque Macaca mulatta XP_001114248 2471 265649 E2461 G P G T H M S E P P H N N M Q
Dog Lupus familis XP_853041 2129 224888 P2121 R P P G K M T P L I G S K V A
Cat Felis silvestris
Mouse Mus musculus Q61982 2318 244229 L2297 H P I S V P S L P Q S Q T Q L
Rat Rattus norvegicus Q9R172 2319 244282 L2298 H P I S V P S L P Q S Q T Q L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512292 2467 261963 E2456 G P G A R G A E P P P R S N T
Chicken Gallus gallus XP_415420 2590 279561 S2506 L P T S L P S S L A Q P M T T
Frog Xenopus laevis P21783 2524 275106 S2511 G I S S P P T S M Q P Q R T H
Zebra Danio Brachydanio rerio P46530 2437 262289 T2425 E G I S S P P T S M Q M N H I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P07207 2703 288835 N2685 V Q S P A A N N L Y I S G G H
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P14585 1429 157097 S1410 W Y T R A S T S Y T Q M Q N E
Sea Urchin Strong. purpuratus P10079 1064 112055 S1057 K W T R Y E Q S I A P Q P D A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 48.9 49.4 77.9 N.A. 90.9 91.4 N.A. 49.4 47.4 47 48.3 N.A. 39.7 N.A. 21.9 21.9
Protein Similarity: 100 62 63 80.9 N.A. 93.8 94 N.A. 61.6 61.2 61.5 62.2 N.A. 52.8 N.A. 33.3 30.5
P-Site Identity: 100 26.6 20 13.3 N.A. 33.3 33.3 N.A. 6.6 66.6 26.6 20 N.A. 6.6 N.A. 20 13.3
P-Site Similarity: 100 46.6 26.6 33.3 N.A. 40 40 N.A. 20 73.3 46.6 33.3 N.A. 33.3 N.A. 33.3 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 8 16 8 8 0 0 24 0 8 0 0 24 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % D
% Glu: 16 0 0 0 0 8 0 16 0 0 0 0 0 0 8 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 24 16 16 8 0 8 0 0 0 0 8 0 8 8 0 % G
% His: 16 0 0 0 8 0 0 0 0 0 8 0 0 8 16 % H
% Ile: 0 8 24 0 0 0 0 0 8 8 8 0 0 8 8 % I
% Lys: 8 0 0 0 8 0 0 0 0 0 0 0 8 0 0 % K
% Leu: 16 0 8 0 8 0 0 16 31 0 0 0 0 0 16 % L
% Met: 0 0 0 0 0 16 0 0 8 16 0 16 8 8 0 % M
% Asn: 0 0 0 0 0 0 8 8 0 0 0 8 16 16 0 % N
% Pro: 0 54 8 8 8 54 16 8 31 16 24 8 8 0 0 % P
% Gln: 0 8 0 0 0 0 8 0 0 24 39 31 24 16 16 % Q
% Arg: 8 0 0 16 8 0 0 0 0 0 0 8 8 0 0 % R
% Ser: 0 0 16 54 16 8 39 39 16 0 16 24 8 0 0 % S
% Thr: 0 0 24 8 0 0 24 16 0 8 0 0 16 24 16 % T
% Val: 8 0 8 0 24 0 0 0 0 0 0 0 0 8 0 % V
% Trp: 8 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 0 0 8 0 0 0 8 8 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _