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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH3
All Species:
7.88
Human Site:
T1724
Identified Species:
14.44
UniProt:
Q9UM47
Number Species:
12
Phosphosite Substitution
Charge Score:
0.58
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UM47
NP_000426.2
2321
243659
T1724
V
A
T
D
W
M
D
T
E
C
P
E
A
K
R
Chimpanzee
Pan troglodytes
XP_520371
2555
272693
E1816
N
Q
N
E
W
G
D
E
D
L
E
T
K
K
F
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
D1761
T
S
E
H
W
V
D
D
E
G
P
Q
P
K
K
Dog
Lupus familis
XP_853041
2129
224888
V1711
L
V
I
L
V
L
G
V
M
V
A
R
R
K
R
Cat
Felis silvestris
Mouse
Mus musculus
Q61982
2318
244229
S1725
V
V
T
D
L
N
D
S
E
C
P
E
A
K
R
Rat
Rattus norvegicus
Q9R172
2319
244282
S1726
V
A
T
D
W
N
D
S
E
C
P
E
A
K
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
D1757
P
G
Q
R
W
L
S
D
G
G
P
Q
S
K
R
Chicken
Gallus gallus
XP_415420
2590
279561
E1854
N
Q
N
E
W
G
D
E
E
T
L
D
T
K
K
Frog
Xenopus laevis
P21783
2524
275106
E1810
N
Q
N
E
W
G
D
E
E
T
L
E
N
K
R
Zebra Danio
Brachydanio rerio
P46530
2437
262289
D1805
Q
L
S
E
W
A
E
D
D
T
N
K
R
F
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
M1828
W
S
D
D
E
S
D
M
P
L
P
K
R
Q
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
H1058
R
H
N
R
T
V
L
H
W
I
A
S
N
S
S
Sea Urchin
Strong. purpuratus
P10079
1064
112055
E693
I
D
R
V
D
S
Y
E
C
V
C
A
A
G
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
48.9
49.4
77.9
N.A.
90.9
91.4
N.A.
49.4
47.4
47
48.3
N.A.
39.7
N.A.
21.9
21.9
Protein Similarity:
100
62
63
80.9
N.A.
93.8
94
N.A.
61.6
61.2
61.5
62.2
N.A.
52.8
N.A.
33.3
30.5
P-Site Identity:
100
20
33.3
13.3
N.A.
73.3
86.6
N.A.
26.6
26.6
40
13.3
N.A.
26.6
N.A.
0
6.6
P-Site Similarity:
100
33.3
60
26.6
N.A.
80
93.3
N.A.
46.6
46.6
46.6
46.6
N.A.
46.6
N.A.
6.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
16
0
0
0
8
0
0
0
0
16
8
31
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
8
24
8
0
0
0
0
% C
% Asp:
0
8
8
31
8
0
62
24
16
0
0
8
0
0
0
% D
% Glu:
0
0
8
31
8
0
8
31
47
0
8
31
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
8
% F
% Gly:
0
8
0
0
0
24
8
0
8
16
0
0
0
8
0
% G
% His:
0
8
0
8
0
0
0
8
0
0
0
0
0
0
0
% H
% Ile:
8
0
8
0
0
0
0
0
0
8
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
16
8
70
16
% K
% Leu:
8
8
0
8
8
16
8
0
0
16
16
0
0
0
0
% L
% Met:
0
0
0
0
0
8
0
8
8
0
0
0
0
0
0
% M
% Asn:
24
0
31
0
0
16
0
0
0
0
8
0
16
0
0
% N
% Pro:
8
0
0
0
0
0
0
0
8
0
47
0
8
0
0
% P
% Gln:
8
24
8
0
0
0
0
0
0
0
0
16
0
8
0
% Q
% Arg:
8
0
8
16
0
0
0
0
0
0
0
8
24
0
62
% R
% Ser:
0
16
8
0
0
16
8
16
0
0
0
8
8
8
8
% S
% Thr:
8
0
24
0
8
0
0
8
0
24
0
8
8
0
0
% T
% Val:
24
16
0
8
8
16
0
8
0
16
0
0
0
0
0
% V
% Trp:
8
0
0
0
62
0
0
0
8
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _