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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH3
All Species:
16.67
Human Site:
T2270
Identified Species:
30.56
UniProt:
Q9UM47
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UM47
NP_000426.2
2321
243659
T2270
L
S
D
W
S
E
S
T
P
S
P
A
T
A
T
Chimpanzee
Pan troglodytes
XP_520371
2555
272693
T2337
V
A
P
G
P
L
S
T
Q
A
P
S
L
Q
H
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
P2422
L
T
P
S
P
E
S
P
D
Q
W
S
S
S
S
Dog
Lupus familis
XP_853041
2129
224888
P2079
L
L
D
Q
P
S
G
P
R
S
P
H
G
P
H
Cat
Felis silvestris
Mouse
Mus musculus
Q61982
2318
244229
T2270
L
S
D
W
S
D
S
T
P
S
P
A
T
A
T
Rat
Rattus norvegicus
Q9R172
2319
244282
T2271
L
S
D
W
S
D
S
T
P
S
P
A
T
A
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
P2417
L
T
P
S
P
E
S
P
D
Q
W
S
S
S
S
Chicken
Gallus gallus
XP_415420
2590
279561
L2499
L
P
Q
D
S
Q
L
L
P
T
S
L
P
S
S
Frog
Xenopus laevis
P21783
2524
275106
T2466
Y
S
S
P
M
D
N
T
P
S
H
Q
L
Q
V
Zebra Danio
Brachydanio rerio
P46530
2437
262289
T2382
Y
S
N
P
M
D
N
T
P
N
H
Q
Q
V
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
S2502
V
G
Q
G
P
Q
N
S
P
V
S
L
G
I
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
G1385
P
E
Y
Q
T
E
A
G
S
S
E
A
F
Q
P
Sea Urchin
Strong. purpuratus
P10079
1064
112055
G1020
G
Q
C
H
L
C
D
G
E
E
V
L
Y
T
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
48.9
49.4
77.9
N.A.
90.9
91.4
N.A.
49.4
47.4
47
48.3
N.A.
39.7
N.A.
21.9
21.9
Protein Similarity:
100
62
63
80.9
N.A.
93.8
94
N.A.
61.6
61.2
61.5
62.2
N.A.
52.8
N.A.
33.3
30.5
P-Site Identity:
100
20
20
26.6
N.A.
93.3
93.3
N.A.
20
20
26.6
20
N.A.
6.6
N.A.
20
6.6
P-Site Similarity:
100
46.6
53.3
26.6
N.A.
100
100
N.A.
53.3
46.6
40
46.6
N.A.
33.3
N.A.
33.3
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
0
8
0
0
8
0
31
0
24
0
% A
% Cys:
0
0
8
0
0
8
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
31
8
0
31
8
0
16
0
0
0
0
0
0
% D
% Glu:
0
8
0
0
0
31
0
0
8
8
8
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% F
% Gly:
8
8
0
16
0
0
8
16
0
0
0
0
16
0
0
% G
% His:
0
0
0
8
0
0
0
0
0
0
16
8
0
0
16
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
8
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
54
8
0
0
8
8
8
8
0
0
0
24
16
0
0
% L
% Met:
0
0
0
0
16
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
8
0
0
0
24
0
0
8
0
0
0
0
0
% N
% Pro:
8
8
24
16
39
0
0
24
54
0
39
0
8
8
16
% P
% Gln:
0
8
16
16
0
16
0
0
8
16
0
16
8
24
0
% Q
% Arg:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% R
% Ser:
0
39
8
16
31
8
47
8
8
47
16
24
16
24
24
% S
% Thr:
0
16
0
0
8
0
0
47
0
8
0
0
24
8
31
% T
% Val:
16
0
0
0
0
0
0
0
0
8
8
0
0
8
8
% V
% Trp:
0
0
0
24
0
0
0
0
0
0
16
0
0
0
0
% W
% Tyr:
16
0
8
0
0
0
0
0
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _