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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH3
All Species:
13.64
Human Site:
T2314
Identified Species:
25
UniProt:
Q9UM47
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UM47
NP_000426.2
2321
243659
T2314
L
G
P
Q
P
E
V
T
P
K
R
Q
V
L
A
Chimpanzee
Pan troglodytes
XP_520371
2555
272693
Q2416
Q
P
P
P
P
P
P
Q
P
H
L
G
V
S
S
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
S2460
R
G
P
G
T
H
M
S
E
P
P
H
N
N
M
Dog
Lupus familis
XP_853041
2129
224888
T2120
R
R
P
P
G
K
M
T
P
L
I
G
S
K
V
Cat
Felis silvestris
Mouse
Mus musculus
Q61982
2318
244229
T2311
L
G
P
Q
P
E
V
T
P
K
R
Q
V
M
A
Rat
Rattus norvegicus
Q9R172
2319
244282
T2312
L
G
P
Q
P
E
V
T
P
K
R
Q
V
M
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
R2460
R
G
A
E
P
P
P
R
S
N
T
Q
V
F
A
Chicken
Gallus gallus
XP_415420
2590
279561
T2546
V
P
D
H
P
F
L
T
P
S
P
E
S
P
D
Frog
Xenopus laevis
P21783
2524
275106
Q2513
S
S
P
P
T
S
M
Q
P
Q
R
T
H
I
P
Zebra Danio
Brachydanio rerio
P46530
2437
262289
N2430
P
P
T
S
M
Q
M
N
H
I
P
E
A
F
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
Q2545
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
H
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
Sea Urchin
Strong. purpuratus
P10079
1064
112055
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
48.9
49.4
77.9
N.A.
90.9
91.4
N.A.
49.4
47.4
47
48.3
N.A.
39.7
N.A.
21.9
21.9
Protein Similarity:
100
62
63
80.9
N.A.
93.8
94
N.A.
61.6
61.2
61.5
62.2
N.A.
52.8
N.A.
33.3
30.5
P-Site Identity:
100
26.6
13.3
20
N.A.
93.3
93.3
N.A.
33.3
20
20
0
N.A.
13.3
N.A.
0
0
P-Site Similarity:
100
33.3
26.6
33.3
N.A.
100
100
N.A.
40
40
40
20
N.A.
33.3
N.A.
0
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
0
0
0
0
0
0
0
8
0
31
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
8
% D
% Glu:
0
0
0
8
0
24
0
0
8
0
0
16
0
0
0
% E
% Phe:
0
0
0
0
0
8
0
0
0
0
0
0
0
16
0
% F
% Gly:
0
39
0
8
8
0
0
0
0
0
0
16
0
0
0
% G
% His:
0
0
0
8
0
8
0
0
8
8
0
8
8
8
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
8
8
0
0
8
0
% I
% Lys:
0
0
0
0
0
8
0
0
0
24
0
0
0
8
8
% K
% Leu:
24
0
0
0
0
0
8
0
0
8
8
0
0
8
0
% L
% Met:
0
0
0
0
8
0
31
0
0
0
0
0
0
16
8
% M
% Asn:
0
0
0
0
0
0
0
8
0
8
0
0
8
8
0
% N
% Pro:
8
24
54
24
47
16
16
0
54
8
24
0
0
8
8
% P
% Gln:
16
8
8
31
8
16
8
24
8
16
8
39
8
0
8
% Q
% Arg:
24
8
0
0
0
0
0
8
0
0
31
0
0
0
0
% R
% Ser:
8
8
0
8
0
8
0
8
8
8
0
0
16
8
8
% S
% Thr:
0
0
8
0
16
0
0
39
0
0
8
8
0
0
0
% T
% Val:
8
0
0
0
0
0
24
0
0
0
0
0
39
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _