KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH3
All Species:
9.7
Human Site:
Y2244
Identified Species:
17.78
UniProt:
Q9UM47
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UM47
NP_000426.2
2321
243659
Y2244
R
V
P
S
E
H
P
Y
L
T
P
S
P
E
S
Chimpanzee
Pan troglodytes
XP_520371
2555
272693
G2317
W
L
S
R
L
Q
S
G
M
V
P
N
Q
Y
N
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
F2376
I
L
P
A
Y
H
P
F
P
A
S
V
G
K
Y
Dog
Lupus familis
XP_853041
2129
224888
D2054
R
E
I
T
D
H
L
D
R
L
P
R
D
V
A
Cat
Felis silvestris
Mouse
Mus musculus
Q61982
2318
244229
Y2244
R
V
P
S
E
H
P
Y
L
T
P
S
P
E
S
Rat
Rattus norvegicus
Q9R172
2319
244282
Y2245
R
V
P
S
E
H
P
Y
L
T
P
S
P
E
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
F2371
V
L
P
A
Y
H
P
F
P
S
S
V
G
K
Y
Chicken
Gallus gallus
XP_415420
2590
279561
Q2445
Q
Q
P
Q
Q
Q
P
Q
Q
Q
P
Q
P
Q
Q
Frog
Xenopus laevis
P21783
2524
275106
I2422
Q
Q
M
S
S
N
N
I
H
S
V
M
P
Q
D
Zebra Danio
Brachydanio rerio
P46530
2437
262289
R2356
I
L
P
Q
D
S
Q
R
M
A
P
P
I
S
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
H2454
S
L
P
T
S
P
T
H
I
Q
A
M
R
H
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
T1368
H
F
M
N
T
T
H
T
T
P
T
S
L
N
Y
Sea Urchin
Strong. purpuratus
P10079
1064
112055
D1003
F
G
F
T
V
V
R
D
N
G
Q
S
T
T
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
48.9
49.4
77.9
N.A.
90.9
91.4
N.A.
49.4
47.4
47
48.3
N.A.
39.7
N.A.
21.9
21.9
Protein Similarity:
100
62
63
80.9
N.A.
93.8
94
N.A.
61.6
61.2
61.5
62.2
N.A.
52.8
N.A.
33.3
30.5
P-Site Identity:
100
6.6
20
20
N.A.
100
100
N.A.
20
26.6
13.3
20
N.A.
6.6
N.A.
6.6
13.3
P-Site Similarity:
100
33.3
46.6
40
N.A.
100
100
N.A.
53.3
46.6
40
40
N.A.
40
N.A.
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
16
0
0
0
0
0
16
8
0
0
0
16
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
16
0
0
16
0
0
0
0
8
0
8
% D
% Glu:
0
8
0
0
24
0
0
0
0
0
0
0
0
24
0
% E
% Phe:
8
8
8
0
0
0
0
16
0
0
0
0
0
0
0
% F
% Gly:
0
8
0
0
0
0
0
8
0
8
0
0
16
0
0
% G
% His:
8
0
0
0
0
47
8
8
8
0
0
0
0
8
0
% H
% Ile:
16
0
8
0
0
0
0
8
8
0
0
0
8
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
16
0
% K
% Leu:
0
39
0
0
8
0
8
0
24
8
0
0
8
0
0
% L
% Met:
0
0
16
0
0
0
0
0
16
0
0
16
0
0
0
% M
% Asn:
0
0
0
8
0
8
8
0
8
0
0
8
0
8
8
% N
% Pro:
0
0
62
0
0
8
47
0
16
8
54
8
39
0
0
% P
% Gln:
16
16
0
16
8
16
8
8
8
16
8
8
8
16
8
% Q
% Arg:
31
0
0
8
0
0
8
8
8
0
0
8
8
0
0
% R
% Ser:
8
0
8
31
16
8
8
0
0
16
16
39
0
8
39
% S
% Thr:
0
0
0
24
8
8
8
8
8
24
8
0
8
8
0
% T
% Val:
8
24
0
0
8
8
0
0
0
8
8
16
0
8
0
% V
% Trp:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
16
0
0
24
0
0
0
0
0
8
24
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _