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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PRPF19 All Species: 35.45
Human Site: S70 Identified Species: 60
UniProt: Q9UMS4 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UMS4 NP_055317.1 504 55181 S70 P K P P S A T S I P A I L K A
Chimpanzee Pan troglodytes XP_508466 495 54079 P66 H P I R P K P P S A T S I P A
Rhesus Macaque Macaca mulatta XP_001084826 895 97815 S461 P K P P S A T S I P A I L K A
Dog Lupus familis XP_853782 504 55132 S70 P K P P S A T S I P A I L K A
Cat Felis silvestris
Mouse Mus musculus Q99KP6 504 55220 S70 P K P P S A T S I P A I L K A
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q5ZMA2 505 55116 S70 P R P P S A T S I P A I L K A
Frog Xenopus laevis Q90ZL4 410 46744
Zebra Danio Brachydanio rerio NP_958875 505 54715 S70 P K A P S A T S I P A I L K S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7KNS3 411 46441
Honey Bee Apis mellifera XP_392284 504 55033 S70 P K P P S A T S I P A I L K I
Nematode Worm Caenorhab. elegans Q10051 492 53189 R65 G G T G S A P R N V S G T S I
Sea Urchin Strong. purpuratus XP_001204257 498 53907 S70 P R P P T A T S I P A I L K L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q94BR4 523 56848 S68 P K P L H T A S I P G L L G T
Baker's Yeast Sacchar. cerevisiae P32523 503 56552 T66 Q A S L T E S T N S A T L K A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.6 56.3 99.4 N.A. 99.4 N.A. N.A. N.A. 94 22 85.3 N.A. 21.8 67.6 51.7 65.4
Protein Similarity: 100 95.4 56.3 99.8 N.A. 99.8 N.A. N.A. N.A. 96.6 39 94.6 N.A. 36.5 82.3 69.8 78.5
P-Site Identity: 100 6.6 100 100 N.A. 100 N.A. N.A. N.A. 93.3 0 86.6 N.A. 0 93.3 13.3 80
P-Site Similarity: 100 13.3 100 100 N.A. 100 N.A. N.A. N.A. 100 0 93.3 N.A. 0 93.3 20 93.3
Percent
Protein Identity: N.A. N.A. N.A. 42.4 23.4 N.A.
Protein Similarity: N.A. N.A. N.A. 61.1 43.8 N.A.
P-Site Identity: N.A. N.A. N.A. 46.6 26.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 53.3 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 8 0 0 65 8 0 0 8 65 0 0 0 50 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 8 8 0 8 0 0 0 0 0 0 8 8 0 8 0 % G
% His: 8 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 8 0 0 0 0 0 65 0 0 58 8 0 15 % I
% Lys: 0 50 0 0 0 8 0 0 0 0 0 0 0 65 0 % K
% Leu: 0 0 0 15 0 0 0 0 0 0 0 8 72 0 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 15 0 0 0 0 0 0 % N
% Pro: 65 8 58 58 8 0 15 8 0 65 0 0 0 8 0 % P
% Gln: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 15 0 8 0 0 0 8 0 0 0 0 0 0 0 % R
% Ser: 0 0 8 0 58 0 8 65 8 8 8 8 0 8 8 % S
% Thr: 0 0 8 0 15 8 58 8 0 0 8 8 8 0 8 % T
% Val: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _