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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRPF19
All Species:
23.94
Human Site:
T259
Identified Species:
40.51
UniProt:
Q9UMS4
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UMS4
NP_055317.1
504
55181
T259
S
S
E
Q
I
L
A
T
L
K
G
H
T
K
K
Chimpanzee
Pan troglodytes
XP_508466
495
54079
F249
A
D
K
N
V
V
V
F
D
K
S
S
E
Q
I
Rhesus Macaque
Macaca mulatta
XP_001084826
895
97815
T650
S
S
E
Q
I
L
A
T
L
K
G
H
T
K
K
Dog
Lupus familis
XP_853782
504
55132
T259
S
S
E
Q
I
L
A
T
L
K
G
H
T
K
K
Cat
Felis silvestris
Mouse
Mus musculus
Q99KP6
504
55220
T259
S
T
E
Q
I
L
A
T
L
K
G
H
T
K
K
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZMA2
505
55116
T260
S
S
E
Q
I
L
A
T
L
K
G
H
S
K
K
Frog
Xenopus laevis
Q90ZL4
410
46744
A166
D
H
S
G
K
L
L
A
S
C
S
A
D
M
T
Zebra Danio
Brachydanio rerio
NP_958875
505
54715
T260
R
E
E
Q
I
V
A
T
L
K
G
H
T
K
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q7KNS3
411
46441
S167
A
Q
G
K
L
L
A
S
C
S
A
D
L
S
I
Honey Bee
Apis mellifera
XP_392284
504
55033
A258
K
D
T
E
Q
V
V
A
I
L
K
G
H
T
K
Nematode Worm
Caenorhab. elegans
Q10051
492
53189
K248
E
Q
V
M
Q
T
F
K
G
H
N
K
K
I
N
Sea Urchin
Strong. purpuratus
XP_001204257
498
53907
F254
A
D
R
N
A
V
V
F
N
K
D
T
E
Q
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q94BR4
523
56848
H263
I
L
S
T
L
T
G
H
S
K
K
V
T
S
I
Baker's Yeast
Sacchar. cerevisiae
P32523
503
56552
N255
I
I
S
R
G
P
C
N
R
L
L
L
L
Y
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.6
56.3
99.4
N.A.
99.4
N.A.
N.A.
N.A.
94
22
85.3
N.A.
21.8
67.6
51.7
65.4
Protein Similarity:
100
95.4
56.3
99.8
N.A.
99.8
N.A.
N.A.
N.A.
96.6
39
94.6
N.A.
36.5
82.3
69.8
78.5
P-Site Identity:
100
6.6
100
100
N.A.
93.3
N.A.
N.A.
N.A.
93.3
6.6
80
N.A.
13.3
6.6
0
6.6
P-Site Similarity:
100
40
100
100
N.A.
100
N.A.
N.A.
N.A.
100
6.6
86.6
N.A.
40
26.6
0
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
42.4
23.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
61.1
43.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
22
0
0
0
8
0
50
15
0
0
8
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
8
0
8
8
0
0
0
0
0
% C
% Asp:
8
22
0
0
0
0
0
0
8
0
8
8
8
0
0
% D
% Glu:
8
8
43
8
0
0
0
0
0
0
0
0
15
0
0
% E
% Phe:
0
0
0
0
0
0
8
15
0
0
0
0
0
0
0
% F
% Gly:
0
0
8
8
8
0
8
0
8
0
43
8
0
0
0
% G
% His:
0
8
0
0
0
0
0
8
0
8
0
43
8
0
0
% H
% Ile:
15
8
0
0
43
0
0
0
8
0
0
0
0
8
22
% I
% Lys:
8
0
8
8
8
0
0
8
0
65
15
8
8
43
50
% K
% Leu:
0
8
0
0
15
50
8
0
43
15
8
8
15
0
0
% L
% Met:
0
0
0
8
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
0
15
0
0
0
8
8
0
8
0
0
0
8
% N
% Pro:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
8
% P
% Gln:
0
15
0
43
15
0
0
0
0
0
0
0
0
15
0
% Q
% Arg:
8
0
8
8
0
0
0
0
8
0
0
0
0
0
0
% R
% Ser:
36
29
22
0
0
0
0
8
15
8
15
8
8
15
0
% S
% Thr:
0
8
8
8
0
15
0
43
0
0
0
8
43
8
8
% T
% Val:
0
0
8
0
8
29
22
0
0
0
0
8
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _