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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: VPS4A All Species: 29.7
Human Site: S362 Identified Species: 46.67
UniProt: Q9UN37 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UN37 NP_037377.1 437 48898 S362 F K K V C G P S R T N P S M M
Chimpanzee Pan troglodytes XP_001147558 511 57412 S436 F K K V C G P S R T N P S M M
Rhesus Macaque Macaca mulatta XP_001093648 516 56751 S441 F K K V C G P S R T N P S V M
Dog Lupus familis XP_536805 437 48918 S362 F K K V C G P S R T N P S V M
Cat Felis silvestris
Mouse Mus musculus Q8VEJ9 437 48888 S362 F K K V C G P S R T N P S V M
Rat Rattus norvegicus Q5XIK7 488 55183 A407 D I H L E D I A E K T E G Y S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510255 484 54482 S409 F K K V R G P S R T N P G I I
Chicken Gallus gallus Q1HGK7 492 56020 A411 D V D L A N I A E K M E G Y S
Frog Xenopus laevis Q9PUL2 486 55412 A407 D V N I E C I A E N M D G Y S
Zebra Danio Brachydanio rerio Q5U3S1 488 54873 A407 D V D L T V F A E K I E G Y S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_573258 442 49577 S367 F K R V S G P S P T N H E E I
Honey Bee Apis mellifera XP_393250 441 49311 S366 F K R V R G P S P K D P S I I
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus O61577 516 57575 A435 D I D L K S I A E K M D G Y S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SEX2 523 57218 T444 I E D V A R R T E G Y S G D D
Baker's Yeast Sacchar. cerevisiae P52917 437 48154 V363 S A T H F K D V S T E D D E T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 85.1 84.5 98.8 N.A. 99 36.4 N.A. 83.2 37.4 37.2 35.4 N.A. 74.2 77 N.A. 34.5
Protein Similarity: 100 85.3 84.6 99.7 N.A. 100 55.5 N.A. 87.1 54.2 55.7 56.7 N.A. 85.9 88.8 N.A. 52.3
P-Site Identity: 100 100 93.3 93.3 N.A. 93.3 0 N.A. 73.3 0 0 0 N.A. 53.3 53.3 N.A. 0
P-Site Similarity: 100 100 100 100 N.A. 100 13.3 N.A. 86.6 13.3 13.3 13.3 N.A. 66.6 80 N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. 36.5 60.8 N.A.
Protein Similarity: N.A. N.A. N.A. 54.6 76.4 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 0 0 14 0 0 34 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 34 7 0 0 0 0 0 0 0 0 0 % C
% Asp: 34 0 27 0 0 7 7 0 0 0 7 20 7 7 7 % D
% Glu: 0 7 0 0 14 0 0 0 40 0 7 20 7 14 0 % E
% Phe: 54 0 0 0 7 0 7 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 54 0 0 0 7 0 0 47 0 0 % G
% His: 0 0 7 7 0 0 0 0 0 0 0 7 0 0 0 % H
% Ile: 7 14 0 7 0 0 27 0 0 0 7 0 0 14 20 % I
% Lys: 0 54 40 0 7 7 0 0 0 34 0 0 0 0 0 % K
% Leu: 0 0 0 27 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 20 0 0 14 34 % M
% Asn: 0 0 7 0 0 7 0 0 0 7 47 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 54 0 14 0 0 47 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 14 0 14 7 7 0 40 0 0 0 0 0 0 % R
% Ser: 7 0 0 0 7 7 0 54 7 0 0 7 40 0 34 % S
% Thr: 0 0 7 0 7 0 0 7 0 54 7 0 0 0 7 % T
% Val: 0 20 0 60 0 7 0 7 0 0 0 0 0 20 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 7 0 0 34 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _