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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: VPS4A All Species: 51.21
Human Site: T249 Identified Species: 80.48
UniProt: Q9UN37 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UN37 NP_037377.1 437 48898 T249 E A A R R I K T E F L V Q M Q
Chimpanzee Pan troglodytes XP_001147558 511 57412 T323 E A A R R I K T E F L V Q M Q
Rhesus Macaque Macaca mulatta XP_001093648 516 56751 T328 E A A R R I K T E F L V Q M Q
Dog Lupus familis XP_536805 437 48918 T249 E A A R R I K T E F L V Q M Q
Cat Felis silvestris
Mouse Mus musculus Q8VEJ9 437 48888 T249 E A A R R I K T E F L V Q M Q
Rat Rattus norvegicus Q5XIK7 488 55183 S283 T S K Y R G E S E K L V R L L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510255 484 54482 T296 E A A R R I K T E F L V Q M Q
Chicken Gallus gallus Q1HGK7 492 56020 S287 T S K Y R G E S E K L V R L L
Frog Xenopus laevis Q9PUL2 486 55412 S283 T S K Y R G E S E K L V R L L
Zebra Danio Brachydanio rerio Q5U3S1 488 54873 S283 T S K Y R G E S E K L V R L L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_573258 442 49577 T254 D S V R R I K T E F L V Q M Q
Honey Bee Apis mellifera XP_393250 441 49311 T253 E S A R R I K T E F L V Q M Q
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus O61577 516 57575 S311 T S K Y H G E S E K L V R L L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SEX2 523 57218 S316 A S K W R G E S E R M V R C L
Baker's Yeast Sacchar. cerevisiae P52917 437 48154 T254 E A S R R I K T E L L V Q M N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 85.1 84.5 98.8 N.A. 99 36.4 N.A. 83.2 37.4 37.2 35.4 N.A. 74.2 77 N.A. 34.5
Protein Similarity: 100 85.3 84.6 99.7 N.A. 100 55.5 N.A. 87.1 54.2 55.7 56.7 N.A. 85.9 88.8 N.A. 52.3
P-Site Identity: 100 100 100 100 N.A. 100 26.6 N.A. 100 26.6 26.6 26.6 N.A. 80 93.3 N.A. 20
P-Site Similarity: 100 100 100 100 N.A. 100 60 N.A. 100 60 60 60 N.A. 93.3 100 N.A. 53.3
Percent
Protein Identity: N.A. N.A. N.A. 36.5 60.8 N.A.
Protein Similarity: N.A. N.A. N.A. 54.6 76.4 N.A.
P-Site Identity: N.A. N.A. N.A. 20 80 N.A.
P-Site Similarity: N.A. N.A. N.A. 53.3 86.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 47 47 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % C
% Asp: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 54 0 0 0 0 0 40 0 100 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 54 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 40 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 60 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 40 0 0 0 60 0 0 34 0 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 7 94 0 0 34 40 % L
% Met: 0 0 0 0 0 0 0 0 0 0 7 0 0 60 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 60 0 54 % Q
% Arg: 0 0 0 60 94 0 0 0 0 7 0 0 40 0 0 % R
% Ser: 0 54 7 0 0 0 0 40 0 0 0 0 0 0 0 % S
% Thr: 34 0 0 0 0 0 0 60 0 0 0 0 0 0 0 % T
% Val: 0 0 7 0 0 0 0 0 0 0 0 100 0 0 0 % V
% Trp: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 34 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _