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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: COPS3 All Species: 26.67
Human Site: S268 Identified Species: 39.11
UniProt: Q9UNS2 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UNS2 NP_003644.2 423 47873 S268 H E L A Q V Y S T N N P S E L
Chimpanzee Pan troglodytes XP_001160462 403 45708 L255 S T N N P S E L R N L V N K H
Rhesus Macaque Macaca mulatta XP_001089619 403 45805 L255 S T N N P S E L R N L V N K H
Dog Lupus familis XP_536667 423 47885 S268 H E L A Q V Y S T N N P S E L
Cat Felis silvestris
Mouse Mus musculus O88543 423 47814 S268 H E L A Q V Y S T N N P S E L
Rat Rattus norvegicus Q68FW9 423 47841 S268 H E L A Q V Y S T N N P S E L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510734 403 45736 L255 S T N N P S E L R N L V N K H
Chicken Gallus gallus Q5ZJF1 423 47944 S268 H E L A Q V Y S T N K P S E L
Frog Xenopus laevis Q7ZTN8 423 47776 S268 H E L A Q V Y S T N N P A E L
Zebra Danio Brachydanio rerio Q6P2U9 423 47889 A268 H E L A Q I Y A T N N P A E L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q8SYG2 445 50685 A284 H D L V N V Y A N S S S E E L
Honey Bee Apis mellifera XP_624761 445 50628 Q274 Q E L A T A Y Q M N S C E E V
Nematode Worm Caenorhab. elegans Q9N425 501 55865 S346 Q F S E I R F S R S S N T H S
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001149499 424 47039 S266 A E L S T S Y S N G S K T D L
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8W575 429 47723 N268 I E L G N C Y N D G K I G E L
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7S7G7 497 55199 K303 K L F A Q A F K S E T A G D L
Conservation
Percent
Protein Identity: 100 95.2 93.6 99.7 N.A. 99.5 99.7 N.A. 94.5 98.5 93.8 93.6 N.A. 51 60.9 20.9 N.A.
Protein Similarity: 100 95.2 94.3 99.7 N.A. 100 100 N.A. 95.2 99 97.8 98.1 N.A. 68.7 77 39.3 N.A.
P-Site Identity: 100 6.6 6.6 100 N.A. 100 100 N.A. 6.6 93.3 93.3 80 N.A. 40 40 6.6 N.A.
P-Site Similarity: 100 20 20 100 N.A. 100 100 N.A. 20 93.3 100 100 N.A. 66.6 53.3 33.3 N.A.
Percent
Protein Identity: N.A. 41.2 N.A. 38.9 N.A. 22.1
Protein Similarity: N.A. 61 N.A. 57.5 N.A. 39.4
P-Site Identity: N.A. 33.3 N.A. 33.3 N.A. 20
P-Site Similarity: N.A. 60 N.A. 40 N.A. 40
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 57 0 13 0 13 0 0 0 7 13 0 0 % A
% Cys: 0 0 0 0 0 7 0 0 0 0 0 7 0 0 0 % C
% Asp: 0 7 0 0 0 0 0 0 7 0 0 0 0 13 0 % D
% Glu: 0 63 0 7 0 0 19 0 0 7 0 0 13 63 0 % E
% Phe: 0 7 7 0 0 0 13 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 7 0 0 0 0 0 13 0 0 13 0 0 % G
% His: 50 0 0 0 0 0 0 0 0 0 0 0 0 7 19 % H
% Ile: 7 0 0 0 7 7 0 0 0 0 0 7 0 0 0 % I
% Lys: 7 0 0 0 0 0 0 7 0 0 13 7 0 19 0 % K
% Leu: 0 7 69 0 0 0 0 19 0 0 19 0 0 0 69 % L
% Met: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % M
% Asn: 0 0 19 19 13 0 0 7 13 69 38 7 19 0 0 % N
% Pro: 0 0 0 0 19 0 0 0 0 0 0 44 0 0 0 % P
% Gln: 13 0 0 0 50 0 0 7 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 7 0 0 25 0 0 0 0 0 0 % R
% Ser: 19 0 7 7 0 25 0 50 7 13 25 7 32 0 7 % S
% Thr: 0 19 0 0 13 0 0 0 44 0 7 0 13 0 0 % T
% Val: 0 0 0 7 0 44 0 0 0 0 0 19 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 69 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _