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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CYP8B1
All Species:
14.85
Human Site:
T470
Identified Species:
36.3
UniProt:
Q9UNU6
Number Species:
9
Phosphosite Substitution
Charge Score:
0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UNU6
NP_004382
501
58078
T470
L
E
L
V
D
P
D
T
P
L
P
H
V
D
P
Chimpanzee
Pan troglodytes
XP_001140682
501
57917
T470
L
E
L
V
D
P
D
T
P
L
P
H
V
D
P
Rhesus Macaque
Macaca mulatta
XP_001108578
446
51344
T415
L
E
L
V
D
P
D
T
P
L
P
H
V
D
P
Dog
Lupus familis
XP_542738
501
57779
T470
L
E
L
V
D
P
N
T
P
V
P
P
V
D
P
Cat
Felis silvestris
Mouse
Mus musculus
O88962
500
57688
I469
F
K
L
V
D
P
D
I
P
V
P
P
I
D
P
Rat
Rattus norvegicus
Q62969
501
57109
D471
D
L
E
L
V
S
E
D
T
E
V
P
E
F
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507523
486
55712
E453
L
E
L
K
N
P
E
E
P
I
P
K
F
D
K
Chicken
Gallus gallus
P05180
491
56243
T451
M
E
I
F
L
F
L
T
S
I
L
Q
N
F
S
Frog
Xenopus laevis
NP_001079792
293
33913
I263
K
E
N
I
S
G
W
I
G
E
Q
H
Q
Q
R
Zebra Danio
Brachydanio rerio
NP_001003736
510
58430
P479
F
D
F
E
L
T
N
P
N
E
Q
I
P
G
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
85
81
N.A.
75
41.9
N.A.
38.3
23.1
27.3
51.1
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.4
86.4
88.2
N.A.
85.6
58.8
N.A.
57
41.1
41.9
70.1
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
80
N.A.
60
0
N.A.
46.6
13.3
13.3
0
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
80
13.3
N.A.
66.6
33.3
20
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
10
0
0
50
0
40
10
0
0
0
0
0
60
10
% D
% Glu:
0
70
10
10
0
0
20
10
0
30
0
0
10
0
0
% E
% Phe:
20
0
10
10
0
10
0
0
0
0
0
0
10
20
0
% F
% Gly:
0
0
0
0
0
10
0
0
10
0
0
0
0
10
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
40
0
0
0
% H
% Ile:
0
0
10
10
0
0
0
20
0
20
0
10
10
0
10
% I
% Lys:
10
10
0
10
0
0
0
0
0
0
0
10
0
0
10
% K
% Leu:
50
10
60
10
20
0
10
0
0
30
10
0
0
0
0
% L
% Met:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
10
0
10
0
20
0
10
0
0
0
10
0
0
% N
% Pro:
0
0
0
0
0
60
0
10
60
0
60
30
10
0
50
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
20
10
10
10
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% R
% Ser:
0
0
0
0
10
10
0
0
10
0
0
0
0
0
10
% S
% Thr:
0
0
0
0
0
10
0
50
10
0
0
0
0
0
0
% T
% Val:
0
0
0
50
10
0
0
0
0
20
10
0
40
0
0
% V
% Trp:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _