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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TTF2 All Species: 13.33
Human Site: S505 Identified Species: 24.44
UniProt: Q9UNY4 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UNY4 NP_003585.3 1162 129588 S505 R G T Q P V G S L E L K S A C
Chimpanzee Pan troglodytes XP_513683 1162 129565 S505 R G T Q P V G S L E L K S A C
Rhesus Macaque Macaca mulatta XP_001112999 1163 129401 S506 C G T Q P V G S L E L K S A C
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q5NC05 1138 125512 S481 P L I Q P A S S L G L K A G R
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_416595 1178 129334 S518 P S A A A L G S S E Y F G H G
Frog Xenopus laevis NP_001084942 1187 131668 L528 G S A P V P S L S Q N F S S L
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P34739 1061 118357 G434 V L A E D P V G L K V S L M N
Honey Bee Apis mellifera XP_393754 954 109196 E344 S L V A R P T E E E R A N D P
Nematode Worm Caenorhab. elegans NP_502137 1091 122548 D441 K R I Q L V S D R V V R Q L A
Sea Urchin Strong. purpuratus XP_787293 600 68137
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FIY7 1277 144314 F492 E I M L Y V S F Y I H S S I F
Baker's Yeast Sacchar. cerevisiae P31244 790 91412 G179 Q R S K Q P D G M T I K L L P
Red Bread Mold Neurospora crassa Q7S1P9 1222 137173 S481 A L Y K K A Q S F D F S T P E
Conservation
Percent
Protein Identity: 100 99.1 95.8 N.A. N.A. 70.3 N.A. N.A. N.A. 53.5 51 N.A. N.A. 32.1 31.8 28.3 26.8
Protein Similarity: 100 99.4 96.9 N.A. N.A. 79.6 N.A. N.A. N.A. 66.2 66.8 N.A. N.A. 51.2 49.3 48.5 37.3
P-Site Identity: 100 100 93.3 N.A. N.A. 40 N.A. N.A. N.A. 20 6.6 N.A. N.A. 6.6 6.6 13.3 0
P-Site Similarity: 100 100 93.3 N.A. N.A. 46.6 N.A. N.A. N.A. 26.6 20 N.A. N.A. 26.6 13.3 33.3 0
Percent
Protein Identity: N.A. N.A. N.A. 23.1 21.3 21.3
Protein Similarity: N.A. N.A. N.A. 42.6 37.8 39.9
P-Site Identity: N.A. N.A. N.A. 13.3 6.6 6.6
P-Site Similarity: N.A. N.A. N.A. 13.3 40 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 24 16 8 16 0 0 0 0 0 8 8 24 8 % A
% Cys: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 24 % C
% Asp: 0 0 0 0 8 0 8 8 0 8 0 0 0 8 0 % D
% Glu: 8 0 0 8 0 0 0 8 8 39 0 0 0 0 8 % E
% Phe: 0 0 0 0 0 0 0 8 8 0 8 16 0 0 8 % F
% Gly: 8 24 0 0 0 0 31 16 0 8 0 0 8 8 8 % G
% His: 0 0 0 0 0 0 0 0 0 0 8 0 0 8 0 % H
% Ile: 0 8 16 0 0 0 0 0 0 8 8 0 0 8 0 % I
% Lys: 8 0 0 16 8 0 0 0 0 8 0 39 0 0 0 % K
% Leu: 0 31 0 8 8 8 0 8 39 0 31 0 16 16 8 % L
% Met: 0 0 8 0 0 0 0 0 8 0 0 0 0 8 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 8 0 8 0 8 % N
% Pro: 16 0 0 8 31 31 0 0 0 0 0 0 0 8 16 % P
% Gln: 8 0 0 39 8 0 8 0 0 8 0 0 8 0 0 % Q
% Arg: 16 16 0 0 8 0 0 0 8 0 8 8 0 0 8 % R
% Ser: 8 16 8 0 0 0 31 47 16 0 0 24 39 8 0 % S
% Thr: 0 0 24 0 0 0 8 0 0 8 0 0 8 0 0 % T
% Val: 8 0 8 0 8 39 8 0 0 8 16 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 0 8 0 0 0 8 0 8 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _