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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TTF2 All Species: 16.97
Human Site: S636 Identified Species: 31.11
UniProt: Q9UNY4 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UNY4 NP_003585.3 1162 129588 S636 T W L S K D D S C D F T S H G
Chimpanzee Pan troglodytes XP_513683 1162 129565 S636 T W L S K D D S C D F T S H G
Rhesus Macaque Macaca mulatta XP_001112999 1163 129401 S637 T W L S K D D S S E L T S H G
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q5NC05 1138 125512 S612 T W L S K N D S S V F T S S G
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_416595 1178 129334 S647 V W L S R N D S T V I P S C S
Frog Xenopus laevis NP_001084942 1187 131668 S657 E W I S K T D S T L V V T R G
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P34739 1061 118357 L552 S K V S R Q K L T V C V H H G
Honey Bee Apis mellifera XP_393754 954 109196 V459 C K R G M L S V E V Y H G T N
Nematode Worm Caenorhab. elegans NP_502137 1091 122548 E563 L I H Q W D A E I D R R L D D
Sea Urchin Strong. purpuratus XP_787293 600 68137 E105 M L W R E A Q E S P C G G I L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9FIY7 1277 144314 G692 L A D A M G L G K T V M T I A
Baker's Yeast Sacchar. cerevisiae P31244 790 91412 Q294 L E S V F R K Q N Y G F R R K
Red Bread Mold Neurospora crassa Q7S1P9 1222 137173 P621 V N N L P R L P T V S G Q K T
Conservation
Percent
Protein Identity: 100 99.1 95.8 N.A. N.A. 70.3 N.A. N.A. N.A. 53.5 51 N.A. N.A. 32.1 31.8 28.3 26.8
Protein Similarity: 100 99.4 96.9 N.A. N.A. 79.6 N.A. N.A. N.A. 66.2 66.8 N.A. N.A. 51.2 49.3 48.5 37.3
P-Site Identity: 100 100 80 N.A. N.A. 73.3 N.A. N.A. N.A. 40 40 N.A. N.A. 20 0 13.3 0
P-Site Similarity: 100 100 86.6 N.A. N.A. 80 N.A. N.A. N.A. 53.3 53.3 N.A. N.A. 40 6.6 13.3 6.6
Percent
Protein Identity: N.A. N.A. N.A. 23.1 21.3 21.3
Protein Similarity: N.A. N.A. N.A. 42.6 37.8 39.9
P-Site Identity: N.A. N.A. N.A. 0 0 0
P-Site Similarity: N.A. N.A. N.A. 13.3 0 0
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 8 0 8 8 0 0 0 0 0 0 0 8 % A
% Cys: 8 0 0 0 0 0 0 0 16 0 16 0 0 8 0 % C
% Asp: 0 0 8 0 0 31 47 0 0 24 0 0 0 8 8 % D
% Glu: 8 8 0 0 8 0 0 16 8 8 0 0 0 0 0 % E
% Phe: 0 0 0 0 8 0 0 0 0 0 24 8 0 0 0 % F
% Gly: 0 0 0 8 0 8 0 8 0 0 8 16 16 0 47 % G
% His: 0 0 8 0 0 0 0 0 0 0 0 8 8 31 0 % H
% Ile: 0 8 8 0 0 0 0 0 8 0 8 0 0 16 0 % I
% Lys: 0 16 0 0 39 0 16 0 8 0 0 0 0 8 8 % K
% Leu: 24 8 39 8 0 8 16 8 0 8 8 0 8 0 8 % L
% Met: 8 0 0 0 16 0 0 0 0 0 0 8 0 0 0 % M
% Asn: 0 8 8 0 0 16 0 0 8 0 0 0 0 0 8 % N
% Pro: 0 0 0 0 8 0 0 8 0 8 0 8 0 0 0 % P
% Gln: 0 0 0 8 0 8 8 8 0 0 0 0 8 0 0 % Q
% Arg: 0 0 8 8 16 16 0 0 0 0 8 8 8 16 0 % R
% Ser: 8 0 8 54 0 0 8 47 24 0 8 0 39 8 8 % S
% Thr: 31 0 0 0 0 8 0 0 31 8 0 31 16 8 8 % T
% Val: 16 0 8 8 0 0 0 8 0 39 16 16 0 0 0 % V
% Trp: 0 47 8 0 8 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 8 8 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _