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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TFR2 All Species: 8.79
Human Site: S64 Identified Species: 17.58
UniProt: Q9UP52 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UP52 NP_003218.2 801 88755 S64 R G P E P L G S R P R Q P N L
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001113151 672 74384
Dog Lupus familis XP_546952 806 88711 S63 L R G P D L G S R T G G Q S L
Cat Felis silvestris
Mouse Mus musculus Q9JKX3 798 88384 S62 K G P E H L G S C P G R S I P
Rat Rattus norvegicus B2GUY2 798 88309 S62 K G P E R L G S C P G R S I P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516658 498 55112
Chicken Gallus gallus Q90997 776 85640 N65 S M A Q P Q R N G K R L C F L
Frog Xenopus laevis NP_001089576 754 85283 W46 R A T L F T G W L I K P S E E
Zebra Danio Brachydanio rerio NP_001009916 783 85895 A56 T L N S D I T A L M L Q Q H V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P91406 770 85483 N50 H H S E R K F N K F N K V S I
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9M1S8 705 77149 Q21 I S I I P F R Q P P P L C S F
Baker's Yeast Sacchar. cerevisiae P47161 811 91999 S62 N D S F T L T S R N R G R S N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 81.9 87 N.A. 84.5 83.5 N.A. 32 38.8 26.8 49.8 N.A. N.A. N.A. 22.6 N.A.
Protein Similarity: 100 N.A. 82.6 91.8 N.A. 89.8 89.5 N.A. 44.8 55.5 46.4 65 N.A. N.A. N.A. 41.4 N.A.
P-Site Identity: 100 N.A. 0 33.3 N.A. 46.6 46.6 N.A. 0 20 13.3 6.6 N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: 100 N.A. 0 40 N.A. 60 60 N.A. 0 33.3 20 33.3 N.A. N.A. N.A. 40 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 26 21.7 N.A.
Protein Similarity: N.A. N.A. N.A. 40.5 39.7 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 26.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 9 9 0 0 0 0 9 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 17 0 0 0 17 0 0 % C
% Asp: 0 9 0 0 17 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 34 0 0 0 0 0 0 0 0 0 9 9 % E
% Phe: 0 0 0 9 9 9 9 0 0 9 0 0 0 9 9 % F
% Gly: 0 25 9 0 0 0 42 0 9 0 25 17 0 0 0 % G
% His: 9 9 0 0 9 0 0 0 0 0 0 0 0 9 0 % H
% Ile: 9 0 9 9 0 9 0 0 0 9 0 0 0 17 9 % I
% Lys: 17 0 0 0 0 9 0 0 9 9 9 9 0 0 0 % K
% Leu: 9 9 0 9 0 42 0 0 17 0 9 17 0 0 25 % L
% Met: 0 9 0 0 0 0 0 0 0 9 0 0 0 0 0 % M
% Asn: 9 0 9 0 0 0 0 17 0 9 9 0 0 9 9 % N
% Pro: 0 0 25 9 25 0 0 0 9 34 9 9 9 0 17 % P
% Gln: 0 0 0 9 0 9 0 9 0 0 0 17 17 0 0 % Q
% Arg: 17 9 0 0 17 0 17 0 25 0 25 17 9 0 0 % R
% Ser: 9 9 17 9 0 0 0 42 0 0 0 0 25 34 0 % S
% Thr: 9 0 9 0 9 9 17 0 0 9 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 9 % V
% Trp: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _