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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: COG5 All Species: 18.18
Human Site: S206 Identified Species: 28.57
UniProt: Q9UP83 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.21
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UP83 NP_006339.3 839 92719 S206 E I T K A A Q S L N E L D Y L
Chimpanzee Pan troglodytes XP_001163243 839 92761 S206 E I T K A A Q S L N E L D Y L
Rhesus Macaque Macaca mulatta XP_001091632 839 93187 S206 E I T K A A Q S L N E L D Y L
Dog Lupus familis XP_540384 915 100544 S261 E I T K A A Q S L N E L D Y L
Cat Felis silvestris
Mouse Mus musculus Q8C0L8 829 91582 E192 G I D L S R I E V I E N D L L
Rat Rattus norvegicus XP_001076141 873 96086 S219 E I T K A A Q S L N E L D Y L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509241 830 91568 E192 G I D L S G I E V I E S D L L
Chicken Gallus gallus XP_415949 817 90713 E180 G I D L S G I E V I E N D L L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001038609 810 89826 V177 V D L S G I D V I E N D L L F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VJD3 751 84935 A174 R A Y V I S S A Q K I R N L T
Honey Bee Apis mellifera XP_624919 536 60039
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_795770 559 62030
Poplar Tree Populus trichocarpa XP_002302138 844 92630 L215 D L A K A A Q L H R E I L T M
Maize Zea mays NP_001169223 818 89889 G203 Y E E K N L S G I N A V D E E
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_176960 832 91633 F200 D L T K A A Q F H F E I L T M
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 95.9 85.6 N.A. 86.2 84.5 N.A. 83.5 82.5 N.A. 74.2 N.A. 25.6 28.7 N.A. 41
Protein Similarity: 100 99.7 97.5 88.4 N.A. 90.6 89.3 N.A. 89.6 88.4 N.A. 84.1 N.A. 44.9 43.3 N.A. 53.5
P-Site Identity: 100 100 100 100 N.A. 26.6 100 N.A. 26.6 26.6 N.A. 0 N.A. 0 0 N.A. 0
P-Site Similarity: 100 100 100 100 N.A. 40 100 N.A. 40 40 N.A. 6.6 N.A. 20 0 N.A. 0
Percent
Protein Identity: 28.3 24.2 N.A. 27.7 N.A. N.A.
Protein Similarity: 48.7 45.4 N.A. 49.7 N.A. N.A.
P-Site Identity: 33.3 20 N.A. 40 N.A. N.A.
P-Site Similarity: 60 33.3 N.A. 66.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 7 0 47 47 0 7 0 0 7 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 14 7 20 0 0 0 7 0 0 0 0 7 60 0 0 % D
% Glu: 34 7 7 0 0 0 0 20 0 7 67 0 0 7 7 % E
% Phe: 0 0 0 0 0 0 0 7 0 7 0 0 0 0 7 % F
% Gly: 20 0 0 0 7 14 0 7 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 14 0 0 0 0 0 0 % H
% Ile: 0 54 0 0 7 7 20 0 14 20 7 14 0 0 0 % I
% Lys: 0 0 0 54 0 0 0 0 0 7 0 0 0 0 0 % K
% Leu: 0 14 7 20 0 7 0 7 34 0 0 34 20 34 54 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 14 % M
% Asn: 0 0 0 0 7 0 0 0 0 40 7 14 7 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 47 0 7 0 0 0 0 0 0 % Q
% Arg: 7 0 0 0 0 7 0 0 0 7 0 7 0 0 0 % R
% Ser: 0 0 0 7 20 7 14 34 0 0 0 7 0 0 0 % S
% Thr: 0 0 40 0 0 0 0 0 0 0 0 0 0 14 7 % T
% Val: 7 0 0 7 0 0 0 7 20 0 0 7 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 7 0 7 0 0 0 0 0 0 0 0 0 0 34 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _