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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SLC12A4 All Species: 33.94
Human Site: S438 Identified Species: 74.67
UniProt: Q9UP95 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UP95 NP_001139433.1 1085 120650 S438 V T G I M A G S N R S G D L R
Chimpanzee Pan troglodytes XP_001173480 1150 127612 S503 V T G I M A G S N R S G D L K
Rhesus Macaque Macaca mulatta XP_001096210 1080 120177 S433 V T G I M A G S N R S G D L R
Dog Lupus familis XP_856607 1102 122537 S455 V T G I M A G S N R S G D L K
Cat Felis silvestris
Mouse Mus musculus Q9JIS8 1085 120605 S438 V T G I M A G S N R S G D L R
Rat Rattus norvegicus Q63632 1085 120609 S438 V T G I M A G S N R S G D L R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505237 1093 121937 S446 V T G I M A G S N R S G D L K
Chicken Gallus gallus XP_001234005 1136 125676 S491 V T G I M A G S N R S G D L K
Frog Xenopus laevis Q0VGW6 899 98326 F314 I A V I I T F F V Y L I L F I
Zebra Danio Brachydanio rerio A2BFP5 899 98457 Y314 G T I M A V A Y T F T V Y V L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q09573 1020 112280 Y426 L T T S A I Y Y I L A I L F G
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 72.7 98.3 75.7 N.A. 96.2 96.5 N.A. 87.5 79.2 25.9 25.8 N.A. N.A. N.A. 35.7 N.A.
Protein Similarity: 100 82.7 98.8 85.8 N.A. 98 98.1 N.A. 93.5 86.8 43.9 43.6 N.A. N.A. N.A. 55.3 N.A.
P-Site Identity: 100 93.3 100 93.3 N.A. 100 100 N.A. 93.3 93.3 6.6 6.6 N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 100 20 26.6 N.A. N.A. N.A. 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 0 0 19 73 10 0 0 0 10 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 73 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 10 10 0 10 0 0 0 19 0 % F
% Gly: 10 0 73 0 0 0 73 0 0 0 0 73 0 0 10 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 10 0 10 82 10 10 0 0 10 0 0 19 0 0 10 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 37 % K
% Leu: 10 0 0 0 0 0 0 0 0 10 10 0 19 73 10 % L
% Met: 0 0 0 10 73 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 73 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 73 0 0 0 0 37 % R
% Ser: 0 0 0 10 0 0 0 73 0 0 73 0 0 0 0 % S
% Thr: 0 91 10 0 0 10 0 0 10 0 10 0 0 0 0 % T
% Val: 73 0 10 0 0 10 0 0 10 0 0 10 0 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 10 19 0 10 0 0 10 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _