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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DOLK All Species: 17.88
Human Site: Y375 Identified Species: 43.7
UniProt: Q9UPQ8 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UPQ8 NP_055723.1 538 59268 Y375 A V F I F L E Y V R Y F R I K
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_537820 536 59260 Y373 T V F I F L E Y V R Y F R I K
Cat Felis silvestris
Mouse Mus musculus Q8R2Y3 534 59127 Y371 A V F I F L E Y V R Y F R I K
Rat Rattus norvegicus NP_001101296 536 59200 Y373 A V F I F L E Y V R Y F R I K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517971 485 52832 F323 L C L A A L V F L E Y V R F F
Chicken Gallus gallus XP_415482 523 58204 Y360 A V F I F L E Y I R Y F R I K
Frog Xenopus laevis NP_001086008 521 57639 L358 C L A V F I L L E Y V R Y F R
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002313531 573 64284 F407 F G A A L A V F L T L E I I R
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_190090 569 63118 L403 D L A F G A A L A V F V A L E
Baker's Yeast Sacchar. cerevisiae P20048 519 58888 K352 Q M D S N F V K I A L S G T I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. N.A. 94.2 N.A. 94.8 94.9 N.A. 69.6 76.2 69.8 N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 N.A. N.A. 96.4 N.A. 96.4 96.4 N.A. 79.3 87.1 83.4 N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 N.A. N.A. 93.3 N.A. 100 100 N.A. 20 93.3 6.6 N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 N.A. N.A. 93.3 N.A. 100 100 N.A. 33.3 100 33.3 N.A. N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: 24.6 N.A. N.A. 26.8 23.4 N.A.
Protein Similarity: 45.2 N.A. N.A. 46 44.8 N.A.
P-Site Identity: 6.6 N.A. N.A. 0 0 N.A.
P-Site Similarity: 26.6 N.A. N.A. 26.6 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 40 0 30 20 10 20 10 0 10 10 0 0 10 0 0 % A
% Cys: 10 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 10 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 50 0 10 10 0 10 0 0 10 % E
% Phe: 10 0 50 10 60 10 0 20 0 0 10 50 0 20 10 % F
% Gly: 0 10 0 0 10 0 0 0 0 0 0 0 10 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 50 0 10 0 0 20 0 0 0 10 60 10 % I
% Lys: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 50 % K
% Leu: 10 20 10 0 10 60 10 20 20 0 20 0 0 10 0 % L
% Met: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 50 0 10 60 0 20 % R
% Ser: 0 0 0 10 0 0 0 0 0 0 0 10 0 0 0 % S
% Thr: 10 0 0 0 0 0 0 0 0 10 0 0 0 10 0 % T
% Val: 0 50 0 10 0 0 30 0 40 10 10 20 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 50 0 10 60 0 10 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _