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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SETD1B All Species: 10
Human Site: S1184 Identified Species: 16.92
UniProt: Q9UPS6 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UPS6 NP_055863.1 1923 208732 S1184 P G A P A V D S L G M E E E V
Chimpanzee Pan troglodytes XP_523492 1707 185692 S1041 E S S S S S S S S S S S S S S
Rhesus Macaque Macaca mulatta XP_001092031 624 66545
Dog Lupus familis XP_543382 1925 209302 S1188 T G A P V T E S S V M E E E V
Cat Felis silvestris
Mouse Mus musculus Q8CFT2 1985 215333 S1245 P R G P M R E S L G T E E E V
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510235 695 75024 T46 R G R D R P S T R T L Q R S R
Chicken Gallus gallus Q5F3P8 2008 223067 I1253 P V E E P E P I V M L E P E V
Frog Xenopus laevis Q66J90 1938 216239 V1138 M E L E D D D V Q K L E Q D V
Zebra Danio Brachydanio rerio Q1LY77 1844 204122 T1095 V K A P S T P T G P P P E E E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001015221 1641 188364 I991 T K R T K K N I Y S D T D E D
Honey Bee Apis mellifera XP_395451 1406 159180 E757 S S S D S S D E E V C S G N F
Nematode Worm Caenorhab. elegans Q18221 1507 171664 P858 K P I P K S H P K H Q E H H H
Sea Urchin Strong. purpuratus XP_791552 1963 220543 P1125 Q L N P F N S P D M L P F S M
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q8X0S9 1313 145607 I664 D D S H S G T I P S I V F D D
Conservation
Percent
Protein Identity: 100 37.3 27.9 91.9 N.A. 87.7 N.A. N.A. 23.1 61.5 55 51 N.A. 24.7 23.9 22.3 21.3
Protein Similarity: 100 50.3 28.8 93.9 N.A. 90.2 N.A. N.A. 26.7 71.1 66.6 63.6 N.A. 39.4 38.6 35.2 35.2
P-Site Identity: 100 6.6 0 60 N.A. 60 N.A. N.A. 6.6 26.6 20 26.6 N.A. 6.6 6.6 13.3 6.6
P-Site Similarity: 100 20 0 66.6 N.A. 66.6 N.A. N.A. 26.6 40 40 40 N.A. 20 20 13.3 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. 22.2
Protein Similarity: N.A. N.A. N.A. N.A. N.A. 35.4
P-Site Identity: N.A. N.A. N.A. N.A. N.A. 0
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. 26.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 22 0 8 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % C
% Asp: 8 8 0 15 8 8 22 0 8 0 8 0 8 15 15 % D
% Glu: 8 8 8 15 0 8 15 8 8 0 0 43 29 43 8 % E
% Phe: 0 0 0 0 8 0 0 0 0 0 0 0 15 0 8 % F
% Gly: 0 22 8 0 0 8 0 0 8 15 0 0 8 0 0 % G
% His: 0 0 0 8 0 0 8 0 0 8 0 0 8 8 8 % H
% Ile: 0 0 8 0 0 0 0 22 0 0 8 0 0 0 0 % I
% Lys: 8 15 0 0 15 8 0 0 8 8 0 0 0 0 0 % K
% Leu: 0 8 8 0 0 0 0 0 15 0 29 0 0 0 0 % L
% Met: 8 0 0 0 8 0 0 0 0 15 15 0 0 0 8 % M
% Asn: 0 0 8 0 0 8 8 0 0 0 0 0 0 8 0 % N
% Pro: 22 8 0 43 8 8 15 15 8 8 8 15 8 0 0 % P
% Gln: 8 0 0 0 0 0 0 0 8 0 8 8 8 0 0 % Q
% Arg: 8 8 15 0 8 8 0 0 8 0 0 0 8 0 8 % R
% Ser: 8 15 22 8 29 22 22 29 15 22 8 15 8 22 8 % S
% Thr: 15 0 0 8 0 15 8 15 0 8 8 8 0 0 0 % T
% Val: 8 8 0 0 8 8 0 8 8 15 0 8 0 0 36 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _