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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SETD1B All Species: 9.7
Human Site: S1326 Identified Species: 16.41
UniProt: Q9UPS6 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.23
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UPS6 NP_055863.1 1923 208732 S1326 H T P G L C G S L A K S Q S T
Chimpanzee Pan troglodytes XP_523492 1707 185692 P1159 S S P I P L L P P P K K R R K
Rhesus Macaque Macaca mulatta XP_001092031 624 66545 I93 F P L G P C Q I D E F Y V G P
Dog Lupus familis XP_543382 1925 209302 S1328 R T P G L C G S L A K S Q S T
Cat Felis silvestris
Mouse Mus musculus Q8CFT2 1985 215333 S1388 R T P G L C G S L A K S Q S T
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510235 695 75024 V164 V K G A R E A V Q H L H S T S
Chicken Gallus gallus Q5F3P8 2008 223067 P1398 I L A K S S H P L G K S Q S T
Frog Xenopus laevis Q66J90 1938 216239 S1346 G R D I L V K S S H L G K S Q
Zebra Danio Brachydanio rerio Q1LY77 1844 204122 D1269 T P G R D L M D R A R G L G K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001015221 1641 188364 A1109 K R N T E Y M A Q M E R E F L
Honey Bee Apis mellifera XP_395451 1406 159180 V875 E D I E T K N V E D E V Q K K
Nematode Worm Caenorhab. elegans Q18221 1507 171664 E976 T S S M K Q E E T A D E K S R
Sea Urchin Strong. purpuratus XP_791552 1963 220543 L1256 F G M E G L G L G L R A N M P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q8X0S9 1313 145607 E782 S E E D R N K E E T G S W V A
Conservation
Percent
Protein Identity: 100 37.3 27.9 91.9 N.A. 87.7 N.A. N.A. 23.1 61.5 55 51 N.A. 24.7 23.9 22.3 21.3
Protein Similarity: 100 50.3 28.8 93.9 N.A. 90.2 N.A. N.A. 26.7 71.1 66.6 63.6 N.A. 39.4 38.6 35.2 35.2
P-Site Identity: 100 13.3 13.3 93.3 N.A. 93.3 N.A. N.A. 0 40 20 6.6 N.A. 0 6.6 13.3 6.6
P-Site Similarity: 100 26.6 13.3 93.3 N.A. 93.3 N.A. N.A. 13.3 40 26.6 13.3 N.A. 20 13.3 26.6 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. 22.2
Protein Similarity: N.A. N.A. N.A. N.A. N.A. 35.4
P-Site Identity: N.A. N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. 6.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 8 0 0 8 8 0 36 0 8 0 0 8 % A
% Cys: 0 0 0 0 0 29 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 8 8 8 0 0 8 8 8 8 0 0 0 0 % D
% Glu: 8 8 8 15 8 8 8 15 15 8 15 8 8 0 0 % E
% Phe: 15 0 0 0 0 0 0 0 0 0 8 0 0 8 0 % F
% Gly: 8 8 15 29 8 0 29 0 8 8 8 15 0 15 0 % G
% His: 8 0 0 0 0 0 8 0 0 15 0 8 0 0 0 % H
% Ile: 8 0 8 15 0 0 0 8 0 0 0 0 0 0 0 % I
% Lys: 8 8 0 8 8 8 15 0 0 0 36 8 15 8 22 % K
% Leu: 0 8 8 0 29 22 8 8 29 8 15 0 8 0 8 % L
% Met: 0 0 8 8 0 0 15 0 0 8 0 0 0 8 0 % M
% Asn: 0 0 8 0 0 8 8 0 0 0 0 0 8 0 0 % N
% Pro: 0 15 29 0 15 0 0 15 8 8 0 0 0 0 15 % P
% Gln: 0 0 0 0 0 8 8 0 15 0 0 0 36 0 8 % Q
% Arg: 15 15 0 8 15 0 0 0 8 0 15 8 8 8 8 % R
% Ser: 15 15 8 0 8 8 0 29 8 0 0 36 8 43 8 % S
% Thr: 15 22 0 8 8 0 0 0 8 8 0 0 0 8 29 % T
% Val: 8 0 0 0 0 8 0 15 0 0 0 8 8 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % W
% Tyr: 0 0 0 0 0 8 0 0 0 0 0 8 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _