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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SETD1B All Species: 15.45
Human Site: S1354 Identified Species: 26.15
UniProt: Q9UPS6 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UPS6 NP_055863.1 1923 208732 S1354 S G G S S G L S L S S P Q V P
Chimpanzee Pan troglodytes XP_523492 1707 185692 P1187 E P P P A T P P Q A K F P G P
Rhesus Macaque Macaca mulatta XP_001092031 624 66545 R121 N I R E N F L R D M C K K Y G
Dog Lupus familis XP_543382 1925 209302 S1356 S G G S S G L S L S S P Q V P
Cat Felis silvestris
Mouse Mus musculus Q8CFT2 1985 215333 S1416 S G S S S G L S L S S P Q V P
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510235 695 75024 E192 G G T E M F W E E H L V H A G
Chicken Gallus gallus Q5F3P8 2008 223067 S1426 T G S S L T L S S P Q V P G S
Frog Xenopus laevis Q66J90 1938 216239 T1374 P L T G N S L T L T S P H I P
Zebra Danio Brachydanio rerio Q1LY77 1844 204122 S1297 D T P L T G N S L S S P H I L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001015221 1641 188364 I1137 N L Q S P N N I V K N N N S P
Honey Bee Apis mellifera XP_395451 1406 159180 N903 C D I Q K M E N S A A E A L I
Nematode Worm Caenorhab. elegans Q18221 1507 171664 V1004 T G S T A T S V V S S R Q S S
Sea Urchin Strong. purpuratus XP_791552 1963 220543 D1284 P S P N D E V D D V D D D I K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q8X0S9 1313 145607 K810 N D T S A L L K K R K L D L P
Conservation
Percent
Protein Identity: 100 37.3 27.9 91.9 N.A. 87.7 N.A. N.A. 23.1 61.5 55 51 N.A. 24.7 23.9 22.3 21.3
Protein Similarity: 100 50.3 28.8 93.9 N.A. 90.2 N.A. N.A. 26.7 71.1 66.6 63.6 N.A. 39.4 38.6 35.2 35.2
P-Site Identity: 100 6.6 6.6 100 N.A. 93.3 N.A. N.A. 6.6 26.6 33.3 40 N.A. 13.3 0 26.6 0
P-Site Similarity: 100 20 26.6 100 N.A. 93.3 N.A. N.A. 6.6 33.3 60 53.3 N.A. 33.3 26.6 53.3 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. 22.2
Protein Similarity: N.A. N.A. N.A. N.A. N.A. 35.4
P-Site Identity: N.A. N.A. N.A. N.A. N.A. 20
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. 40
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 22 0 0 0 0 15 8 0 8 8 0 % A
% Cys: 8 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % C
% Asp: 8 15 0 0 8 0 0 8 15 0 8 8 15 0 0 % D
% Glu: 8 0 0 15 0 8 8 8 8 0 0 8 0 0 0 % E
% Phe: 0 0 0 0 0 15 0 0 0 0 0 8 0 0 0 % F
% Gly: 8 43 15 8 0 29 0 0 0 0 0 0 0 15 15 % G
% His: 0 0 0 0 0 0 0 0 0 8 0 0 22 0 0 % H
% Ile: 0 8 8 0 0 0 0 8 0 0 0 0 0 22 8 % I
% Lys: 0 0 0 0 8 0 0 8 8 8 15 8 8 0 8 % K
% Leu: 0 15 0 8 8 8 50 0 36 0 8 8 0 15 8 % L
% Met: 0 0 0 0 8 8 0 0 0 8 0 0 0 0 0 % M
% Asn: 22 0 0 8 15 8 15 8 0 0 8 8 8 0 0 % N
% Pro: 15 8 22 8 8 0 8 8 0 8 0 36 15 0 50 % P
% Gln: 0 0 8 8 0 0 0 0 8 0 8 0 29 0 0 % Q
% Arg: 0 0 8 0 0 0 0 8 0 8 0 8 0 0 0 % R
% Ser: 22 8 22 43 22 8 8 36 15 36 43 0 0 15 15 % S
% Thr: 15 8 22 8 8 22 0 8 0 8 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 8 8 15 8 0 15 0 22 0 % V
% Trp: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _