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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SETD1B All Species: 21.82
Human Site: S1763 Identified Species: 36.92
UniProt: Q9UPS6 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UPS6 NP_055863.1 1923 208732 S1763 S E Q R R L L S S F T G S C D
Chimpanzee Pan troglodytes XP_523492 1707 185692 I1552 S A I G T S A I M D S D L L K
Rhesus Macaque Macaca mulatta XP_001092031 624 66545 P479 T F G W S P E P C D S P G T P
Dog Lupus familis XP_543382 1925 209302 S1765 S E Q R R L L S S F T G S C D
Cat Felis silvestris
Mouse Mus musculus Q8CFT2 1985 215333 S1825 S E Q R R L L S S F T G S C D
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510235 695 75024 P550 S S S S Q L S P L P L F G S N
Chicken Gallus gallus Q5F3P8 2008 223067 S1848 S E Q R R L L S S F T G S C D
Frog Xenopus laevis Q66J90 1938 216239 S1778 S E Q R R L L S S F T G S C D
Zebra Danio Brachydanio rerio Q1LY77 1844 204122 S1686 S E Q R R L L S S F S C D S D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001015221 1641 188364 N1495 E S E L L K F N Q L K F R K K
Honey Bee Apis mellifera XP_395451 1406 159180 Q1261 S D L L K F N Q L K F R K K Q
Nematode Worm Caenorhab. elegans Q18221 1507 171664 Q1362 N D F F K I N Q L K F R K K M
Sea Urchin Strong. purpuratus XP_791552 1963 220543 V1802 D Q R R F I A V L Q Q Q E E Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q8X0S9 1313 145607 K1168 L R F N Q L K K R K K P V K F
Conservation
Percent
Protein Identity: 100 37.3 27.9 91.9 N.A. 87.7 N.A. N.A. 23.1 61.5 55 51 N.A. 24.7 23.9 22.3 21.3
Protein Similarity: 100 50.3 28.8 93.9 N.A. 90.2 N.A. N.A. 26.7 71.1 66.6 63.6 N.A. 39.4 38.6 35.2 35.2
P-Site Identity: 100 6.6 0 100 N.A. 100 N.A. N.A. 13.3 100 100 73.3 N.A. 0 6.6 0 6.6
P-Site Similarity: 100 13.3 13.3 100 N.A. 100 N.A. N.A. 26.6 100 100 80 N.A. 13.3 20 26.6 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. 22.2
Protein Similarity: N.A. N.A. N.A. N.A. N.A. 35.4
P-Site Identity: N.A. N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 0 0 0 15 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 8 0 0 8 0 36 0 % C
% Asp: 8 15 0 0 0 0 0 0 0 15 0 8 8 0 43 % D
% Glu: 8 43 8 0 0 0 8 0 0 0 0 0 8 8 0 % E
% Phe: 0 8 15 8 8 8 8 0 0 43 15 15 0 0 8 % F
% Gly: 0 0 8 8 0 0 0 0 0 0 0 36 15 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 8 0 0 15 0 8 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 15 8 8 8 0 22 15 0 15 29 15 % K
% Leu: 8 0 8 15 8 58 43 0 29 8 8 0 8 8 0 % L
% Met: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 8 % M
% Asn: 8 0 0 8 0 0 15 8 0 0 0 0 0 0 8 % N
% Pro: 0 0 0 0 0 8 0 15 0 8 0 15 0 0 8 % P
% Gln: 0 8 43 0 15 0 0 15 8 8 8 8 0 0 15 % Q
% Arg: 0 8 8 50 43 0 0 0 8 0 0 15 8 0 0 % R
% Ser: 65 15 8 8 8 8 8 43 43 0 22 0 36 15 0 % S
% Thr: 8 0 0 0 8 0 0 0 0 0 36 0 0 8 0 % T
% Val: 0 0 0 0 0 0 0 8 0 0 0 0 8 0 0 % V
% Trp: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _