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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SETD1B All Species: 11.21
Human Site: S479 Identified Species: 18.97
UniProt: Q9UPS6 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UPS6 NP_055863.1 1923 208732 S479 W S P E P C D S P G T P T L E
Chimpanzee Pan troglodytes XP_523492 1707 185692 S468 R P A S P A R S G S P A P E T
Rhesus Macaque Macaca mulatta XP_001092031 624 66545
Dog Lupus familis XP_543382 1925 209302 S481 W S P E P C D S P G T P T L E
Cat Felis silvestris
Mouse Mus musculus Q8CFT2 1985 215333 S470 W S P E P C D S P G T P T L E
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510235 695 75024
Chicken Gallus gallus Q5F3P8 2008 223067 H489 T M E S E M Q H N S L D S R I
Frog Xenopus laevis Q66J90 1938 216239 E489 R I A M L L K E Q R T Q L H L
Zebra Danio Brachydanio rerio Q1LY77 1844 204122 L505 E M L L K P F L N E R G D S D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001015221 1641 188364 S425 A S S L P I A S H G F N S C S
Honey Bee Apis mellifera XP_395451 1406 159180 A191 E T T K A S K A C V E K L N N
Nematode Worm Caenorhab. elegans Q18221 1507 171664 M292 H D V G P S S M K M S P I P P
Sea Urchin Strong. purpuratus XP_791552 1963 220543 K467 F D D D R G S K R F D D D R G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q8X0S9 1313 145607 D98 D T E S L P G D T L N T V G S
Conservation
Percent
Protein Identity: 100 37.3 27.9 91.9 N.A. 87.7 N.A. N.A. 23.1 61.5 55 51 N.A. 24.7 23.9 22.3 21.3
Protein Similarity: 100 50.3 28.8 93.9 N.A. 90.2 N.A. N.A. 26.7 71.1 66.6 63.6 N.A. 39.4 38.6 35.2 35.2
P-Site Identity: 100 13.3 0 100 N.A. 100 N.A. N.A. 0 0 6.6 0 N.A. 26.6 0 13.3 0
P-Site Similarity: 100 13.3 0 100 N.A. 100 N.A. N.A. 0 6.6 6.6 6.6 N.A. 33.3 20 20 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. 22.2
Protein Similarity: N.A. N.A. N.A. N.A. N.A. 35.4
P-Site Identity: N.A. N.A. N.A. N.A. N.A. 0
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. 6.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 15 0 8 8 8 8 0 0 0 8 0 0 0 % A
% Cys: 0 0 0 0 0 22 0 0 8 0 0 0 0 8 0 % C
% Asp: 8 15 8 8 0 0 22 8 0 0 8 15 15 0 8 % D
% Glu: 15 0 15 22 8 0 0 8 0 8 8 0 0 8 22 % E
% Phe: 8 0 0 0 0 0 8 0 0 8 8 0 0 0 0 % F
% Gly: 0 0 0 8 0 8 8 0 8 29 0 8 0 8 8 % G
% His: 8 0 0 0 0 0 0 8 8 0 0 0 0 8 0 % H
% Ile: 0 8 0 0 0 8 0 0 0 0 0 0 8 0 8 % I
% Lys: 0 0 0 8 8 0 15 8 8 0 0 8 0 0 0 % K
% Leu: 0 0 8 15 15 8 0 8 0 8 8 0 15 22 8 % L
% Met: 0 15 0 8 0 8 0 8 0 8 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 15 0 8 8 0 8 8 % N
% Pro: 0 8 22 0 43 15 0 0 22 0 8 29 8 8 8 % P
% Gln: 0 0 0 0 0 0 8 0 8 0 0 8 0 0 0 % Q
% Arg: 15 0 0 0 8 0 8 0 8 8 8 0 0 15 0 % R
% Ser: 0 29 8 22 0 15 15 36 0 15 8 0 15 8 15 % S
% Thr: 8 15 8 0 0 0 0 0 8 0 29 8 22 0 8 % T
% Val: 0 0 8 0 0 0 0 0 0 8 0 0 8 0 0 % V
% Trp: 22 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _