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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SETD1B All Species: 22.12
Human Site: T1766 Identified Species: 37.44
UniProt: Q9UPS6 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UPS6 NP_055863.1 1923 208732 T1766 R R L L S S F T G S C D S D L
Chimpanzee Pan troglodytes XP_523492 1707 185692 S1555 G T S A I M D S D L L K L N Q
Rhesus Macaque Macaca mulatta XP_001092031 624 66545 S482 W S P E P C D S P G T P T L E
Dog Lupus familis XP_543382 1925 209302 T1768 R R L L S S F T G S C D S D L
Cat Felis silvestris
Mouse Mus musculus Q8CFT2 1985 215333 T1828 R R L L S S F T G S C D S D L
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510235 695 75024 L553 S Q L S P L P L F G S N S Q P
Chicken Gallus gallus Q5F3P8 2008 223067 T1851 R R L L S S F T G S C D S D L
Frog Xenopus laevis Q66J90 1938 216239 T1781 R R L L S S F T G S C D S D L
Zebra Danio Brachydanio rerio Q1LY77 1844 204122 S1689 R R L L S S F S C D S D L L K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001015221 1641 188364 K1498 L L K F N Q L K F R K K Q L K
Honey Bee Apis mellifera XP_395451 1406 159180 F1264 L K F N Q L K F R K K Q L K F
Nematode Worm Caenorhab. elegans Q18221 1507 171664 F1365 F K I N Q L K F R K K M I K F
Sea Urchin Strong. purpuratus XP_791552 1963 220543 Q1805 R F I A V L Q Q Q E E Q V S N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q8X0S9 1313 145607 K1171 N Q L K K R K K P V K F A R S
Conservation
Percent
Protein Identity: 100 37.3 27.9 91.9 N.A. 87.7 N.A. N.A. 23.1 61.5 55 51 N.A. 24.7 23.9 22.3 21.3
Protein Similarity: 100 50.3 28.8 93.9 N.A. 90.2 N.A. N.A. 26.7 71.1 66.6 63.6 N.A. 39.4 38.6 35.2 35.2
P-Site Identity: 100 0 0 100 N.A. 100 N.A. N.A. 13.3 100 100 53.3 N.A. 0 0 0 6.6
P-Site Similarity: 100 13.3 13.3 100 N.A. 100 N.A. N.A. 26.6 100 100 60 N.A. 6.6 6.6 13.3 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. 22.2
Protein Similarity: N.A. N.A. N.A. N.A. N.A. 35.4
P-Site Identity: N.A. N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 15 0 0 0 0 0 0 0 0 8 0 0 % A
% Cys: 0 0 0 0 0 8 0 0 8 0 36 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 15 0 8 8 0 43 0 36 0 % D
% Glu: 0 0 0 8 0 0 0 0 0 8 8 0 0 0 8 % E
% Phe: 8 8 8 8 0 0 43 15 15 0 0 8 0 0 15 % F
% Gly: 8 0 0 0 0 0 0 0 36 15 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 15 0 8 0 0 0 0 0 0 0 8 0 0 % I
% Lys: 0 15 8 8 8 0 22 15 0 15 29 15 0 15 15 % K
% Leu: 15 8 58 43 0 29 8 8 0 8 8 0 22 22 36 % L
% Met: 0 0 0 0 0 8 0 0 0 0 0 8 0 0 0 % M
% Asn: 8 0 0 15 8 0 0 0 0 0 0 8 0 8 8 % N
% Pro: 0 0 8 0 15 0 8 0 15 0 0 8 0 0 8 % P
% Gln: 0 15 0 0 15 8 8 8 8 0 0 15 8 8 8 % Q
% Arg: 50 43 0 0 0 8 0 0 15 8 0 0 0 8 0 % R
% Ser: 8 8 8 8 43 43 0 22 0 36 15 0 43 8 8 % S
% Thr: 0 8 0 0 0 0 0 36 0 0 8 0 8 0 0 % T
% Val: 0 0 0 0 8 0 0 0 0 8 0 0 8 0 0 % V
% Trp: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _