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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DICER1
All Species:
12.42
Human Site:
S1109
Identified Species:
21.03
UniProt:
Q9UPY3
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UPY3
NP_085124.2
1922
218682
S1109
I
D
S
K
S
F
I
S
I
S
N
S
S
S
A
Chimpanzee
Pan troglodytes
XP_001154199
1922
218702
S1109
I
D
S
K
S
F
I
S
I
S
N
S
S
S
A
Rhesus Macaque
Macaca mulatta
XP_001100868
1920
218494
F1107
K
S
I
D
S
K
S
F
I
S
I
S
N
S
S
Dog
Lupus familis
XP_537547
1923
218622
V1110
D
S
K
S
F
I
S
V
A
N
S
S
S
A
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8R418
1916
216802
S1109
I
D
S
K
S
F
I
S
T
C
N
S
S
L
A
Rat
Rattus norvegicus
XP_001068155
1918
216871
S1109
I
D
S
K
S
F
I
S
T
C
N
S
S
L
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510982
1921
218622
I1110
D
S
K
S
F
I
S
I
P
N
S
S
L
A
E
Chicken
Gallus gallus
Q25BN1
1921
218592
I1110
D
S
K
S
F
I
S
I
P
S
S
S
L
V
E
Frog
Xenopus laevis
NP_001163918
1795
204583
L1004
L
N
Q
K
G
K
A
L
P
L
S
S
A
E
R
Zebra Danio
Brachydanio rerio
Q6TV19
1865
210798
L1071
A
G
V
G
A
Q
T
L
P
P
D
F
R
Y
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VCU9
2249
255312
R1313
S
E
V
L
K
K
S
R
E
S
K
Q
K
E
S
Honey Bee
Apis mellifera
NP_001116485
1946
224489
E1108
E
V
L
K
K
S
K
E
S
E
K
T
K
L
I
Nematode Worm
Caenorhab. elegans
P34529
1845
210905
E1023
Q
K
S
I
E
D
Q
E
R
E
T
R
E
N
D
Sea Urchin
Strong. purpuratus
XP_790894
1850
210427
Y1043
S
P
F
P
S
E
K
Y
E
T
F
V
D
Y
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.9
99.3
97
N.A.
93
93.5
N.A.
91.8
92
76.5
79.2
N.A.
27.7
35.8
31.7
43.5
Protein Similarity:
100
99.9
99.7
98.4
N.A.
96.1
96.4
N.A.
95.8
95.9
83.9
85.5
N.A.
44
54.5
49.6
60.7
P-Site Identity:
100
100
33.3
13.3
N.A.
80
80
N.A.
6.6
13.3
13.3
0
N.A.
6.6
6.6
6.6
6.6
P-Site Similarity:
100
100
46.6
33.3
N.A.
80
80
N.A.
26.6
20
40
13.3
N.A.
20
13.3
13.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
8
0
8
0
8
0
0
0
8
15
29
% A
% Cys:
0
0
0
0
0
0
0
0
0
15
0
0
0
0
0
% C
% Asp:
22
29
0
8
0
8
0
0
0
0
8
0
8
0
8
% D
% Glu:
8
8
0
0
8
8
0
15
15
15
0
0
8
15
22
% E
% Phe:
0
0
8
0
22
29
0
8
0
0
8
8
0
0
0
% F
% Gly:
0
8
0
8
8
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
29
0
8
8
0
22
29
15
22
0
8
0
0
0
8
% I
% Lys:
8
8
22
43
15
22
15
0
0
0
15
0
15
0
0
% K
% Leu:
8
0
8
8
0
0
0
15
0
8
0
0
15
22
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
0
0
0
0
0
0
0
15
29
0
8
8
0
% N
% Pro:
0
8
0
8
0
0
0
0
29
8
0
0
0
0
8
% P
% Gln:
8
0
8
0
0
8
8
0
0
0
0
8
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
8
8
0
0
8
8
0
8
% R
% Ser:
15
29
36
22
43
8
36
29
8
36
29
65
36
22
15
% S
% Thr:
0
0
0
0
0
0
8
0
15
8
8
8
0
0
0
% T
% Val:
0
8
15
0
0
0
0
8
0
0
0
8
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
8
0
0
0
0
0
15
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _