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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DICER1
All Species:
18.18
Human Site:
S1468
Identified Species:
30.77
UniProt:
Q9UPY3
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.23
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UPY3
NP_085124.2
1922
218682
S1468
G
A
F
V
K
K
I
S
L
S
P
F
S
T
T
Chimpanzee
Pan troglodytes
XP_001154199
1922
218702
S1468
G
A
F
V
K
K
I
S
L
S
P
F
S
T
T
Rhesus Macaque
Macaca mulatta
XP_001100868
1920
218494
S1466
G
A
F
V
K
K
I
S
L
S
P
F
S
T
T
Dog
Lupus familis
XP_537547
1923
218622
S1469
G
A
F
V
K
K
I
S
L
S
P
F
S
T
T
Cat
Felis silvestris
Mouse
Mus musculus
Q8R418
1916
216802
F1468
R
K
I
S
L
S
P
F
S
A
S
D
S
A
Y
Rat
Rattus norvegicus
XP_001068155
1918
216871
S1468
F
V
K
K
I
P
L
S
P
F
S
T
S
D
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510982
1921
218622
S1469
F
V
K
K
I
S
L
S
P
F
S
T
T
D
S
Chicken
Gallus gallus
Q25BN1
1921
218592
S1469
F
V
K
K
I
S
L
S
H
F
S
T
T
D
S
Frog
Xenopus laevis
NP_001163918
1795
204583
I1363
N
W
L
P
P
G
Y
I
V
N
Q
D
K
N
S
Zebra Danio
Brachydanio rerio
Q6TV19
1865
210798
R1430
E
Y
Y
Y
E
H
I
R
F
I
D
S
M
L
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VCU9
2249
255312
R1672
D
N
Y
N
D
H
H
R
L
N
L
D
E
K
Q
Honey Bee
Apis mellifera
NP_001116485
1946
224489
S1467
N
I
H
E
G
K
L
S
H
L
R
S
K
Q
V
Nematode Worm
Caenorhab. elegans
P34529
1845
210905
R1382
E
G
K
L
S
F
A
R
S
K
E
V
S
N
C
Sea Urchin
Strong. purpuratus
XP_790894
1850
210427
G1402
T
E
T
D
P
D
A
G
F
V
I
D
T
W
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.9
99.3
97
N.A.
93
93.5
N.A.
91.8
92
76.5
79.2
N.A.
27.7
35.8
31.7
43.5
Protein Similarity:
100
99.9
99.7
98.4
N.A.
96.1
96.4
N.A.
95.8
95.9
83.9
85.5
N.A.
44
54.5
49.6
60.7
P-Site Identity:
100
100
100
100
N.A.
6.6
13.3
N.A.
6.6
6.6
0
6.6
N.A.
6.6
13.3
6.6
0
P-Site Similarity:
100
100
100
100
N.A.
13.3
26.6
N.A.
26.6
26.6
20
20
N.A.
20
20
13.3
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
29
0
0
0
0
15
0
0
8
0
0
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% C
% Asp:
8
0
0
8
8
8
0
0
0
0
8
29
0
22
8
% D
% Glu:
15
8
0
8
8
0
0
0
0
0
8
0
8
0
0
% E
% Phe:
22
0
29
0
0
8
0
8
15
22
0
29
0
0
0
% F
% Gly:
29
8
0
0
8
8
0
8
0
0
0
0
0
0
0
% G
% His:
0
0
8
0
0
15
8
0
15
0
0
0
0
0
0
% H
% Ile:
0
8
8
0
22
0
36
8
0
8
8
0
0
0
8
% I
% Lys:
0
8
29
22
29
36
0
0
0
8
0
0
15
8
0
% K
% Leu:
0
0
8
8
8
0
29
0
36
8
8
0
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% M
% Asn:
15
8
0
8
0
0
0
0
0
15
0
0
0
15
0
% N
% Pro:
0
0
0
8
15
8
8
0
15
0
29
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
8
0
0
8
8
% Q
% Arg:
8
0
0
0
0
0
0
22
0
0
8
0
0
0
0
% R
% Ser:
0
0
0
8
8
22
0
58
15
29
29
15
50
0
29
% S
% Thr:
8
0
8
0
0
0
0
0
0
0
0
22
22
29
29
% T
% Val:
0
22
0
29
0
0
0
0
8
8
0
8
0
0
8
% V
% Trp:
0
8
0
0
0
0
0
0
0
0
0
0
0
8
0
% W
% Tyr:
0
8
15
8
0
0
8
0
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _